Ulmusakidian, a new coumarin glycoside and antifungal phenolic compounds from the root bark of Ulmus davidiana var. japonica
- Authors
- Alishir, A.; Yu, J.S.; Park, M.; Kim, J.-C.; Pang, C.; Kim, J.K.; Jang, T.S.; Jung, W.H.; Kim, K.H.
- Issue Date
- 15-Mar-2021
- Publisher
- Elsevier Ltd
- Keywords
- Antifungal activity; Coumarin glycoside; Ulmaceae; Ulmus davidiana var. japonica
- Citation
- Bioorganic and Medicinal Chemistry Letters, v.36
- Journal Title
- Bioorganic and Medicinal Chemistry Letters
- Volume
- 36
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/47850
- DOI
- 10.1016/j.bmcl.2021.127828
- ISSN
- 0960-894X
1464-3405
- Abstract
- Bioactivity-driven LC/MS-based phytochemical analysis of the root bark extract of Ulmus davidiana var. japonica led to the isolation of 10 compounds including a new coumarin glycoside derivative, ulmusakidian (1). The structure of the new compound was elucidated using extensive spectroscopic analyses via 1D and 2D NMR spectroscopic data interpretations, HR-ESIMS, and chemical transformation. The isolated compounds 1–10 were tested for their antifungal activity against human fungal pathogens Cryptococcus neoformans and Candida albicans. Compounds 9 and 10 showed antifungal activity against C. neoformans, with the lowest minimal inhibitory concentration (MIC) of 12.5–25.0 µg/mL, whereas none of the compounds showed antifungal activity against C. albicans. © 2021 Elsevier Ltd
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - College of Biotechnology & Natural Resource > Department of Systems Biotechnology > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/47850)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.