Anodic aluminium oxide membranes for immunoisolation with sufficient oxygen supply for pancreatic islets
- Authors
- Cho, Siwoo; Lee, Sangmin; Jeong, Seong Hee; Kim, Yeongae; Kim, Song Cheol; Hwang, Woonbong; Park, Jaesung
- Issue Date
- May-2013
- Publisher
- ROYAL SOC CHEMISTRY
- Citation
- INTEGRATIVE BIOLOGY, v.5, no.5, pp 828 - 834
- Pages
- 7
- Journal Title
- INTEGRATIVE BIOLOGY
- Volume
- 5
- Number
- 5
- Start Page
- 828
- End Page
- 834
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/47929
- DOI
- 10.1039/c3ib20226g
- ISSN
- 1757-9694
1757-9708
- Abstract
- Immunoisolation membranes have been developed for various cell encapsulations for therapeutic purposes. However effective encapsulation systems have been hindered by low oxygen (O-2) permeability or imperfect immunoisolation caused by either low porosity or non-uniform pore geometry. Here, we report an encapsulation method that uses an anodic aluminum oxide membrane formed by polyethylene oxide self-assembly to obtain nanochannels with both high selectivity in excluding immune molecules and high permeability of nutrients such as glucose, insulin, and O-2. The extracorporeal encapsulation system composed of these membranes allows O-2 flux to meet the O-2 demand of pancreatic islets of Langerhans and provides excellent in vitro viability and functionality of islets.
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Collections - College of Engineering > School of Mechanical Engineering > 1. Journal Articles
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