Baseline Wall Thickness Is Lower in Mucosa-Healed Segments 1 Year After Infliximab in Pediatric Crohn Disease Patients
- Authors
- Kang, Ben; Choi, So Yoon; Chi, Sangah; Lim, Yaeji; Jeon, Tae Yeon; Choe, Yon Ho
- Issue Date
- Feb-2017
- Publisher
- LIPPINCOTT WILLIAMS & WILKINS
- Keywords
- combined immunosuppression; magnetic resonance enterography; mucosal healing
- Citation
- JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION, v.64, no.2, pp 279 - 285
- Pages
- 7
- Journal Title
- JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION
- Volume
- 64
- Number
- 2
- Start Page
- 279
- End Page
- 285
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/48255
- DOI
- 10.1097/MPG.0000000000001222
- ISSN
- 0277-2116
1536-4801
- Abstract
- Objectives: We aimed to quantitatively investigate the therapeutic response to combined immunosuppression treatment by magnetic resonance enterography (MRE) in active luminal Crohn disease (CD) in the pediatric population. Methods: Pediatric patients with moderate-to-severe luminal CD, who received scheduled infliximab and azathioprine, were included in this preliminary study. Ileocolonoscopy and MRE were performed at baseline and at 1 year, and Simple Endoscopic Score for Crohn's Disease (SES-CD) and Magnetic Resonance Index of Activity (MaRIA) scores were calculated. The correlation between SES-CD and MaRIA scores were investigated with analysis per person and per segment. Results: A total of 167 segments from 17 patients were evaluated by both Ileocolonoscopy and MRE. SES-CD and MaRIA scores showed significant correlations on both per-person analysis (rho = 0.699, P < 0.001) and per segment analysis (rho = 0.596, P < 0.001). Analysis according to ileocolonic location of each segment revealed that the correlation strength was strongest in the right colon (p = 0.653, P < 0.001), whereas the correlation in the rectum was statistically insignificant (rho = 0.29, P = 0.096). A comparative analysis of MaRIA components revealed a significantly thinner bowel wall thickness at baseline in endoscopically healed segments (50/65) compared with unhealed segments (15/65) (median 4.3 vs 7.2 nun, P = 0.036). Conclusions: Therapeutic response to combined immunosuppression at 1 year assessed by MRE correlates with ileocolonoscopy in pediatric patients with CD. Bowel wall thickness of the involved segments at baseline may affect treatment response to combined immunosuppression.
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Collections - College of Business & Economics > Department of Applied Statistics > 1. Journal Articles
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