Moisturizing effect of serine-loaded solid lipid nanoparticles and polysaccharide-rich extract of root Phragmites communis incorporated in hydrogel bases
- Authors
- Barua, Sonia; Kim, Hyeongmin; Hong, Seong-Chul; Yoo, Seung-Yup; Shin, Dohyun; Lee, Chung-Lyol; Na, Seon-Jeong; Kim, Yeong Hyo; Jo, Kanghee; Yun, Gyiae; Kim, Joong-Hark; Sohn, Uy Dong; Lee, Jaehwi
- Issue Date
- Feb-2017
- Publisher
- PHARMACEUTICAL SOC KOREA
- Keywords
- Phragmites rhizoma; Reed root extract; Serine; Solid lipid nanoparticles; Skin moisturization
- Citation
- ARCHIVES OF PHARMACAL RESEARCH, v.40, no.2, pp 250 - 257
- Pages
- 8
- Journal Title
- ARCHIVES OF PHARMACAL RESEARCH
- Volume
- 40
- Number
- 2
- Start Page
- 250
- End Page
- 257
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/4878
- DOI
- 10.1007/s12272-016-0846-1
- ISSN
- 0253-6269
1976-3786
- Abstract
- This study evaluated the moisturizing effect of serine-loaded solid lipid nanoparticles (serine-SLN) and polysaccharide-rich reed (Phragmites communis) root extract (RRE) incorporated in hydrogel bases. The hydrogels with serine-SLN and/or RRE were carefully applied on the volar forearm of human volunteers. Their moisturizing efficacy was evaluated by monitoring conductance values using a skin surface hygrometer. The values of the area under the normalized conductance-time curve (AUCC) were developed and compared as a parameter for the water holding capacity of the skin. Hydrogels with serine-SLN did not significantly moisturize the skin, while hydrogel containing 0.25% RRE produced a significant increase in the moisture content of the skin. However, adding more than 0.25% of RRE into the hydrogel base decreased the moisturizing effect due to the marked reduction of viscosity. Significantly enhanced moisturizing effect was observed with the hydrogel containing 0.25% RRE and 3% serine-SLN, with AUCC increased 2.21 times compared to than blank hydrogel. The results imply that effective delivery of serine into the skin is possible using lipid-based nanocarriers and RRE, which could be a promising strategy to moisturize the skin effectively.
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Collections - College of Pharmacy > School of Pharmacy > 1. Journal Articles
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