Effects of Hahella chejuensis -Derived Prodigiosin on UV-Induced ROS Production, Inflammation and Cytotoxicity in HaCaT Human Skin KeratinocytesEffects of Hahella chejuensis-Derived Prodigiosin on UV-Induced ROS Production, Inflammation and Cytotoxicity in HaCaT Human Skin Keratinocytes
- Authors
- Lee, Jieun; Kim, Hyun Ju; Lee, Sang Jun; Lee, Moo-Seung
- Issue Date
- Mar-2021
- Publisher
- 한국미생물·생명공학회
- Keywords
- Prodigiosin; Hahella chejuensis; kratinocyte; UV irradiation
- Citation
- Journal of Microbiology and Biotechnology, v.31, no.3, pp 475 - 482
- Pages
- 8
- Journal Title
- Journal of Microbiology and Biotechnology
- Volume
- 31
- Number
- 3
- Start Page
- 475
- End Page
- 482
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/48930
- DOI
- 10.4014/jmb.2011.11024
- ISSN
- 1017-7825
1738-8872
- Abstract
- Prodigiosins, which are natural tripyrrole red pigments and synthetic derivatives, reportedly have multiple biological effects mainly on various types of cancer cells. However, the effects of bacterial prodigiosin on non-cancerous HaCaT human skin keratinocytes have not been reported. Therefore, the present study aimed to investigate the functional activities of prodigiosin derived from cultures of the bacterium Hahella chejuensis in HaCaT cells. Cell viability, the cell proliferation rate, and reactive oxygen species (ROS) production in vitro were assayed following treatment of HaCaT cells with prodigiosin. Prodigiosin did not cause cytotoxicity and notably increased proliferation of HaCaT cells. Furthermore, prodigiosin reduced ultraviolet (UV) irradiation-induced ROS production and the inflammatory response in HaCaT cells. More importantly, prodigiosin reduced matrix metalloproteinase-9 expression and increased collagen synthesis in UV-irradiated HaCaT cells, demonstrating that it elicits anti-aging effects. In conclusion, our results reveal that H. chejuensisderived prodigiosin is a potential natural product to develop functional cosmetic ingredients.
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Collections - College of Biotechnology & Natural Resource > Department of Systems Biotechnology > 1. Journal Articles
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