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Potent antiviral activity of Agrimonia pilosa, Galla rhois, and their components against SARS-CoV-2open access
- Authors
- Lee, Yeong-Geun; Kang, Kyung Won; Hong, Woojae; Kim, Yeon Hwa; Oh, Jen Taek; Park, Dae Won; Ko, Minsung; Bai, Yung-Feng; Seo, Young-Jin; Lee, Sang-Myeong; Kim, H.; Kang, S.C.
- Issue Date
- Sep-2021
- Publisher
- Elsevier Ltd
- Keywords
- Antiviral agents; Agrimonia pilosa; APRG64; COVID-19; Galla rhois; SARS-CoV-2
- Citation
- Bioorganic and Medicinal Chemistry, v.45
- Journal Title
- Bioorganic and Medicinal Chemistry
- Volume
- 45
- ISSN
- 0968-0896
1464-3391
- Abstract
- Agrimonia pilosa (AP), Galla rhois (RG), and their mixture (APRG64) strongly inhibited SARS-CoV-2 by interfering with multiple steps of the viral life cycle including viral entry and replication. Furthermore, among 12 components identified in APRG64, three displayed strong antiviral activity, ursolic acid (1), quercetin (7), and 1,2,3,4,6-penta-O-galloyl-beta-D-glucose (12). Molecular docking analysis showed these components to bind potently to the spike receptor-binding-domain (RBD) of the SARS-CoV-2 and its variant B.1.1.7. Taken together, these findings indicate APRG64 as a potent drug candidate to treat SARS-CoV-2 and its variants.
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Collections - College of Natural Sciences > Department of Life Science > 1. Journal Articles
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