Anti-inflammatory effects of DA-9601, an extract of Artemisia asiatica, on aceclofenac-induced acute enteritis
DC Field | Value | Language |
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dc.contributor.author | Kim, Ju HWan | - |
dc.contributor.author | Shin, Chang Yell | - |
dc.contributor.author | Jang, Sun Woo | - |
dc.contributor.author | Kim, Dong-Seok | - |
dc.contributor.author | Lee, Wonae | - |
dc.contributor.author | Kim, Hyung-Gun | - |
dc.contributor.author | Kim, Hak Rim | - |
dc.date.accessioned | 2021-09-17T02:40:22Z | - |
dc.date.available | 2021-09-17T02:40:22Z | - |
dc.date.issued | 2021-09 | - |
dc.identifier.issn | 1226-4512 | - |
dc.identifier.issn | 2093-3827 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/49354 | - |
dc.description.abstract | DA-9601 is an extract obtained from Artemisia asiatica, which has been reported to have anti-inflammatory effects on gastrointestinal lesions; however, its possible anti-inflammatory effects on the small intestine have not been studied yet. Therefore, in this study, we investigated the protective effects of DA-9601 against the ACF-induced small intestinal inflammation. Inflammation of the small intestine was confirmed by histological studies and the changes in the CD4+ T cell fraction induced by the inflammation-related cytokines, and the inflammatory reactions were analyzed. Multifocal discrete small necrotic ulcers with intervening normal mucosa were frequently observed after treatment with ACF. The expression of IL-6 , IL- 17, and TNF-α genes was increased in the ACF group; however, it was found to have been significantly decreased in the DA-9601 treated group. In addition, DA-9601 significantly decreased the levels of proinflammatory mediators such as IL-1β, GMCSF, IFN-γ, and TNF-α; the anti-inflammatory cytokine IL-10, on the other hand, was observed to have increased. It is known that inflammatory mediators related to T cell imbalance and dysfunction continuously activate the inflammatory response, causing chronic tissue damage. The fractions of IFN-γ+ Th1 cells, IL-4+ Th2 cells, IL-9+ Th9 cells, IL-17+ Th17 cells, and Foxp3+ Treg cells were significantly decreased upon DA- 9601 treatment. These data suggest that the inflammatory response induced by ACF is reduced by DA-9601 via lowering of the expression of genes encoding the inflammatory cytokines and the concentration of inflammatory mediators. Furthermore, DA-9601 inhibited the acute inflammatory response mediated by T cells, resulting in an improvement in ACF-induced enteritis | - |
dc.format.extent | 10 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | 대한약리학회 | - |
dc.title | Anti-inflammatory effects of DA-9601, an extract of Artemisia asiatica, on aceclofenac-induced acute enteritis | - |
dc.type | Article | - |
dc.identifier.doi | 10.4196/kjpp.2021.25.5.439 | - |
dc.identifier.bibliographicCitation | The Korean Journal of Physiology & Pharmacology, v.25, no.5, pp 439 - 448 | - |
dc.identifier.kciid | ART002751007 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000692197600006 | - |
dc.identifier.scopusid | 2-s2.0-85114672398 | - |
dc.citation.endPage | 448 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 439 | - |
dc.citation.title | The Korean Journal of Physiology & Pharmacology | - |
dc.citation.volume | 25 | - |
dc.type.docType | Article | - |
dc.publisher.location | 대한민국 | - |
dc.subject.keywordAuthor | DA-9601 | - |
dc.subject.keywordAuthor | Inflammation | - |
dc.subject.keywordAuthor | NSAIDs | - |
dc.subject.keywordAuthor | Small intestine | - |
dc.subject.keywordAuthor | T cell | - |
dc.subject.keywordPlus | PROTON-PUMP INHIBITORS | - |
dc.subject.keywordPlus | PATHOGENESIS | - |
dc.subject.keywordPlus | DRUGS | - |
dc.subject.keywordPlus | PREVENTION | - |
dc.subject.keywordPlus | MANAGEMENT | - |
dc.subject.keywordPlus | DISEASE | - |
dc.subject.keywordPlus | LESIONS | - |
dc.subject.keywordPlus | INJURY | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalResearchArea | Physiology | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Physiology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
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