Anti-inflammatory effects of DA-9601, an extract of Artemisia asiatica, on aceclofenac-induced acute enteritis
- Authors
- Kim, Ju HWan; Shin, Chang Yell; Jang, Sun Woo; Kim, Dong-Seok; Lee, Wonae; Kim, Hyung-Gun; Kim, Hak Rim
- Issue Date
- Sep-2021
- Publisher
- 대한약리학회
- Keywords
- DA-9601; Inflammation; NSAIDs; Small intestine; T cell
- Citation
- The Korean Journal of Physiology & Pharmacology, v.25, no.5, pp 439 - 448
- Pages
- 10
- Journal Title
- The Korean Journal of Physiology & Pharmacology
- Volume
- 25
- Number
- 5
- Start Page
- 439
- End Page
- 448
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/49354
- DOI
- 10.4196/kjpp.2021.25.5.439
- ISSN
- 1226-4512
2093-3827
- Abstract
- DA-9601 is an extract obtained from Artemisia asiatica, which has been reported to have anti-inflammatory effects on gastrointestinal lesions; however, its possible anti-inflammatory effects on the small intestine have not been studied yet.
Therefore, in this study, we investigated the protective effects of DA-9601 against the ACF-induced small intestinal inflammation. Inflammation of the small intestine was confirmed by histological studies and the changes in the CD4+ T cell fraction induced by the inflammation-related cytokines, and the inflammatory reactions were analyzed. Multifocal discrete small necrotic ulcers with intervening normal mucosa were frequently observed after treatment with ACF. The expression of IL-6 , IL- 17, and TNF-α genes was increased in the ACF group; however, it was found to have been significantly decreased in the DA-9601 treated group. In addition, DA-9601 significantly decreased the levels of proinflammatory mediators such as IL-1β, GMCSF, IFN-γ, and TNF-α; the anti-inflammatory cytokine IL-10, on the other hand, was observed to have increased. It is known that inflammatory mediators related to T cell imbalance and dysfunction continuously activate the inflammatory response, causing chronic tissue damage. The fractions of IFN-γ+ Th1 cells, IL-4+ Th2 cells, IL-9+ Th9 cells, IL-17+ Th17 cells, and Foxp3+ Treg cells were significantly decreased upon DA- 9601 treatment. These data suggest that the inflammatory response induced by ACF is reduced by DA-9601 via lowering of the expression of genes encoding the inflammatory cytokines and the concentration of inflammatory mediators. Furthermore, DA-9601 inhibited the acute inflammatory response mediated by T cells, resulting in an improvement in ACF-induced enteritis
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