Detailed Information

Cited 0 time in webofscience Cited 0 time in scopus
Metadata Downloads

Autophagy and Digestive Disorders: Advances in Understanding and Therapeutic ApproachesAutophagy and Digestive Disorders: Advances in Understanding and Therapeutic Approaches

Authors
Thein WynnPo Wah WahChoi Won SeokSohn Uy Dong
Issue Date
May-2021
Publisher
한국응용약물학회
Keywords
Functional dyspepsia; Irritable bowel syndrome; Inflammation; Autophagy
Citation
Biomolecules & Therapeutics, v.29, no.4, pp 353 - 364
Pages
12
Journal Title
Biomolecules & Therapeutics
Volume
29
Number
4
Start Page
353
End Page
364
URI
https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/50257
DOI
10.4062/biomolther.2021.086
ISSN
1976-9148
2005-4483
Abstract
The gastrointestinal (GI) tract is a series of hollow organs that is responsible for the digestion and absorption of ingested foods and the excretion of waste. Any changes in the GI tract can lead to GI disorders. GI disorders are highly prevalent in the population and account for substantial morbidity, mortality, and healthcare utilization. GI disorders can be functional, or organic with structural changes. Functional GI disorders include functional dyspepsia and irritable bowel syndrome. Organic GI disorders include inflammation of the GI tract due to chronic infection, drugs, trauma, and other causes. Recent studies have highlighted a new explanatory mechanism for GI disorders. It has been suggested that autophagy, an intracellular homeostatic mechanism, also plays an important role in the pathogenesis of GI disorders. Autophagy has three primary forms: macroautophagy, microautophagy, and chaperone-mediated autophagy. It may affect intestinal homeostasis, host defense against intestinal pathogens, regulation of the gut microbiota, and innate and adaptive immunity. Drugs targeting autophagy could, therefore, have therapeutic potential for treating GI disorders. In this review, we provide an overview of current understanding regarding the evidence for autophagy in GI diseases and updates on potential treatments, including drugs and complementary and alternative medicines.
Files in This Item
There are no files associated with this item.
Appears in
Collections
College of Pharmacy > School of Pharmacy > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Altmetrics

Total Views & Downloads

BROWSE