Autophagy and Digestive Disorders: Advances in Understanding and Therapeutic ApproachesAutophagy and Digestive Disorders: Advances in Understanding and Therapeutic Approaches
- Authors
- Thein Wynn; Po Wah Wah; Choi Won Seok; Sohn Uy Dong
- Issue Date
- May-2021
- Publisher
- 한국응용약물학회
- Keywords
- Functional dyspepsia; Irritable bowel syndrome; Inflammation; Autophagy
- Citation
- Biomolecules & Therapeutics, v.29, no.4, pp 353 - 364
- Pages
- 12
- Journal Title
- Biomolecules & Therapeutics
- Volume
- 29
- Number
- 4
- Start Page
- 353
- End Page
- 364
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/50257
- DOI
- 10.4062/biomolther.2021.086
- ISSN
- 1976-9148
2005-4483
- Abstract
- The gastrointestinal (GI) tract is a series of hollow organs that is responsible for the digestion and absorption of ingested foods and the excretion of waste. Any changes in the GI tract can lead to GI disorders. GI disorders are highly prevalent in the population and account for substantial morbidity, mortality, and healthcare utilization. GI disorders can be functional, or organic with structural changes. Functional GI disorders include functional dyspepsia and irritable bowel syndrome. Organic GI disorders include inflammation of the GI tract due to chronic infection, drugs, trauma, and other causes. Recent studies have highlighted a new explanatory mechanism for GI disorders. It has been suggested that autophagy, an intracellular homeostatic mechanism, also plays an important role in the pathogenesis of GI disorders. Autophagy has three primary forms: macroautophagy, microautophagy, and chaperone-mediated autophagy. It may affect intestinal homeostasis, host defense against intestinal pathogens, regulation of the gut microbiota, and innate and adaptive immunity. Drugs targeting autophagy could, therefore, have therapeutic potential for treating GI disorders. In this review, we provide an overview of current understanding regarding the evidence for autophagy in GI diseases and updates on potential treatments, including drugs and complementary and alternative medicines.
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Collections - College of Pharmacy > School of Pharmacy > 1. Journal Articles
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