Polymeric Nanoparticle-Based Activatable Near-Infrared Nanosensor for Protease Determination In Vivo
DC Field | Value | Language |
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dc.contributor.author | Lee, Seulki | - |
dc.contributor.author | Ryu, Ju Hee | - |
dc.contributor.author | Park, Kyeongsoon | - |
dc.contributor.author | Lee, Aeju | - |
dc.contributor.author | Lee, Seung-Young | - |
dc.contributor.author | Youn, In-Chan | - |
dc.contributor.author | Ahn, Cheol-Hee | - |
dc.contributor.author | Yoon, Soon Man | - |
dc.contributor.author | Myung, Seung-Jae | - |
dc.contributor.author | Moon, Dae Hyuk | - |
dc.contributor.author | Chen, Xiaoyuan | - |
dc.contributor.author | Choi, Kuiwon | - |
dc.contributor.author | Kwon, Ick Chan | - |
dc.contributor.author | Kim, Kwangmeyung | - |
dc.date.accessioned | 2021-10-18T05:40:19Z | - |
dc.date.available | 2021-10-18T05:40:19Z | - |
dc.date.issued | 2009-12 | - |
dc.identifier.issn | 1530-6984 | - |
dc.identifier.issn | 1530-6992 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/50319 | - |
dc.description.abstract | We report here a new protease activatable strategy based on a polymer nanoparticle platform. This nanosensor delivers chemically labeled matrix metalloproteinase (MMP)-activatable fluorogenic peptides to the specific MMPs of interest in vivo. Intravenous administration of the nanosensor in an MMP-positive SCC-7 xenograft tumor and a colon cancer mouse model verified the enzyme specificity of the nanosensor in vivo. The design platform of the nanosensor is flexible and can be fine-tuned for a wide array of applications such as the detection of biomarkers, early diagnosis of disease, and monitoring therapeutic efficacy. | - |
dc.format.extent | 5 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | AMER CHEMICAL SOC | - |
dc.title | Polymeric Nanoparticle-Based Activatable Near-Infrared Nanosensor for Protease Determination In Vivo | - |
dc.type | Article | - |
dc.identifier.doi | 10.1021/nl902709m | - |
dc.identifier.bibliographicCitation | NANO LETTERS, v.9, no.12, pp 4412 - 4416 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000272395400078 | - |
dc.citation.endPage | 4416 | - |
dc.citation.number | 12 | - |
dc.citation.startPage | 4412 | - |
dc.citation.title | NANO LETTERS | - |
dc.citation.volume | 9 | - |
dc.type.docType | Article | - |
dc.publisher.location | 미국 | - |
dc.subject.keywordPlus | MATRIX METALLOPROTEINASES | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordPlus | PROBES | - |
dc.subject.keywordPlus | MECHANISM | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalResearchArea | Materials Science | - |
dc.relation.journalResearchArea | Physics | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Physical | - |
dc.relation.journalWebOfScienceCategory | Nanoscience & Nanotechnology | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Multidisciplinary | - |
dc.relation.journalWebOfScienceCategory | Physics, Applied | - |
dc.relation.journalWebOfScienceCategory | Physics, Condensed Matter | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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