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Polymeric Nanoparticle-Based Activatable Near-Infrared Nanosensor for Protease Determination In Vivo
- Authors
- Lee, Seulki; Ryu, Ju Hee; Park, Kyeongsoon; Lee, Aeju; Lee, Seung-Young; Youn, In-Chan; Ahn, Cheol-Hee; Yoon, Soon Man; Myung, Seung-Jae; Moon, Dae Hyuk; Chen, Xiaoyuan; Choi, Kuiwon; Kwon, Ick Chan; Kim, Kwangmeyung
- Issue Date
- Dec-2009
- Publisher
- AMER CHEMICAL SOC
- Citation
- NANO LETTERS, v.9, no.12, pp 4412 - 4416
- Pages
- 5
- Journal Title
- NANO LETTERS
- Volume
- 9
- Number
- 12
- Start Page
- 4412
- End Page
- 4416
- ISSN
- 1530-6984
1530-6992
- Abstract
- We report here a new protease activatable strategy based on a polymer nanoparticle platform. This nanosensor delivers chemically labeled matrix metalloproteinase (MMP)-activatable fluorogenic peptides to the specific MMPs of interest in vivo. Intravenous administration of the nanosensor in an MMP-positive SCC-7 xenograft tumor and a colon cancer mouse model verified the enzyme specificity of the nanosensor in vivo. The design platform of the nanosensor is flexible and can be fine-tuned for a wide array of applications such as the detection of biomarkers, early diagnosis of disease, and monitoring therapeutic efficacy.
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