Oral protein delivery: Current status and future prospect
- Authors
- Park, Kyeongsoon; Kwon, Ick Chan; Park, Kinam
- Issue Date
- Mar-2011
- Publisher
- ELSEVIER SCIENCE BV
- Keywords
- Protein drugs; Oral protein delivery; Oral formulations; Particulate delivery systems
- Citation
- REACTIVE & FUNCTIONAL POLYMERS, v.71, no.3, pp 280 - 287
- Pages
- 8
- Journal Title
- REACTIVE & FUNCTIONAL POLYMERS
- Volume
- 71
- Number
- 3
- Start Page
- 280
- End Page
- 287
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/50333
- DOI
- 10.1016/j.reactfunctpolym.2010.10.002
- ISSN
- 1381-5148
1873-166X
- Abstract
- Advances in biotechnology have produced therapeutically active proteins on a commercial scale, and therapeutic proteins are now extensively applied in medical practices to treat various diseases. Oral delivery of protein drugs is a highly attractive approach, and, naturally, numerous attempts have been made to develop such formulations. Despite various attempts, however, no clinically useful oral formulations have been developed, and this is mainly due to extremely low bioavailability of protein drugs. The effective oral protein delivery needs to overcome barriers related to poor absorption, poor permeation, and degradation in the gastrointestinal tract. Various strategies have been explored for enhancing the bioavailability of orally administered proteins. They include chemical modification of protein drugs, use of enzyme inhibitors, and exploration of special formulation ingredients, such as absorption enhancers and mucoadhesive polymers. This article examines the current technologies under development for oral protein delivery. (C) 2010 Elsevier Ltd. All rights reserved.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - College of Biotechnology & Natural Resource > Department of Systems Biotechnology > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/50333)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.