Polymeric nanomedicine for cancer therapy
- Authors
- Park, Jae Hyung; Lee, Seulki; Kim, Jong-Ho; Park, Kyeongsoon; Kim, Kwangmeyung; Kwon, Ick Chan
- Issue Date
- Jan-2008
- Publisher
- PERGAMON-ELSEVIER SCIENCE LTD
- Keywords
- polymeric nanomedicine; cancer therapy; angiogenesis; targeted delivery; drug carrier
- Citation
- PROGRESS IN POLYMER SCIENCE, v.33, no.1, pp 113 - 137
- Pages
- 25
- Journal Title
- PROGRESS IN POLYMER SCIENCE
- Volume
- 33
- Number
- 1
- Start Page
- 113
- End Page
- 137
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/50335
- DOI
- 10.1016/j.progpolymsci.2007.09.003
- ISSN
- 0079-6700
1873-1619
- Abstract
- Nanomedicine, an offshoot of nanotechnology, refers to highly specific, molecular-scale medical intervention for treating disease or repairing damaged tissues. In recent years, polymer-based nanomedicine, a field that includes the use of polymer-DNA complexes (polyplexes), polymer-drug conjugates, and polymer micelles bearing hydrophobic drugs, has received increasing attention for its ability to improve the efficacy of cancer therapeutics. Owing to their small size and excellent biocompatibility, nanosized polymer therapeutic agents can circulate in the bloodstream for long periods of time, allowing them to reach the target site. In addition, chemical modification of polymer therapeutic agents with ligands capable of specifically binding receptors that are over-expressed in cancer cells can markedly augment therapeutic efficiency. This review highlights the characteristics of cancer that provide nanodrug targeting opportunities and discusses rational approaches for future development of polymeric nanomedicines. (c) 2007 Elsevier Ltd. All rights reserved.
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Collections - College of Biotechnology & Natural Resource > Department of Systems Biotechnology > 1. Journal Articles
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