The attenuation of experimental lung metastasis by a bile acid acylated-heparin derivative
DC Field | Value | Language |
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dc.contributor.author | Park, Kyeongsoon | - |
dc.contributor.author | Lee, Seok Ki | - |
dc.contributor.author | Son, Dai Hyun | - |
dc.contributor.author | Park, Soo Ah | - |
dc.contributor.author | Kim, Kwangmeyung | - |
dc.contributor.author | Chang, Hyo Won | - |
dc.contributor.author | Jeong, Eun-jeong | - |
dc.contributor.author | Park, Rang-Woon | - |
dc.contributor.author | Kim, In-San | - |
dc.contributor.author | Kwon, Ick Chan | - |
dc.contributor.author | Byun, Youngro | - |
dc.contributor.author | Kim, Sang Yoon | - |
dc.date.accessioned | 2021-10-21T04:40:05Z | - |
dc.date.available | 2021-10-21T04:40:05Z | - |
dc.date.issued | 2007-06 | - |
dc.identifier.issn | 0142-9612 | - |
dc.identifier.issn | 1878-5905 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/50497 | - |
dc.description.abstract | The inhibitory efficacies of new bile acid acylated-heparin derivative (heparin-DOCA) were evaluated on experimental lung metastasis. We evaluated the effect of heparin-DOCA on intercellular interactions including those between B16F10 and thrombin-activated platelets and TNF-alpha-activated HUVECs, and between B16F10 and immobilized mouse P-selectin. In addition, the inhibitory effects of heparin-DOCA on adhesion and invasion of B16F10 to Matrigel were studied. In an animal mouse study, the blood clot formation and the retention of red fluorescence protein (RFP)-B16F10 in lungs were assessed after heparin-DOCA and RFP-B16F10 intravenous administration. Furthermore, we investigated the anti-metastatic effect of heparin-DOCA against lung metastasis induced by B16F10 and SCC7. Heparin-DOCA inhibited intercellular interactions between B16F10 and activated platelets or activated HUVECs by blocking P- and E-selectin-mediated interactions. Moreover, it reduced adhesion and invasion of B16F10 to ECM, thereby affecting the reduction of early retention of B16F10 in the lung. Heparin-DOCA attenuated lung colony formation on the surfaces and in interior of the lung, and attenuated metastasis by B16F10 and SCC7. These results suggest that heparin-DOCA may have potentials as therapeutic agent that prevents tumor metastasis and progression. (c) 2007 Elsevier Ltd. All rights reserved. | - |
dc.format.extent | 10 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | ELSEVIER SCI LTD | - |
dc.title | The attenuation of experimental lung metastasis by a bile acid acylated-heparin derivative | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.biomaterials.2007.02.001 | - |
dc.identifier.bibliographicCitation | BIOMATERIALS, v.28, no.16, pp 2667 - 2676 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000245691900014 | - |
dc.citation.endPage | 2676 | - |
dc.citation.number | 16 | - |
dc.citation.startPage | 2667 | - |
dc.citation.title | BIOMATERIALS | - |
dc.citation.volume | 28 | - |
dc.type.docType | Article | - |
dc.publisher.location | 영국 | - |
dc.subject.keywordAuthor | bile acid acylated-heparin derivative | - |
dc.subject.keywordAuthor | B16F10 melanoma | - |
dc.subject.keywordAuthor | adhesion | - |
dc.subject.keywordAuthor | invasion | - |
dc.subject.keywordAuthor | lung metastasis | - |
dc.subject.keywordPlus | P-SELECTIN | - |
dc.subject.keywordPlus | TUMOR-METASTASIS | - |
dc.subject.keywordPlus | CELL-ADHESION | - |
dc.subject.keywordPlus | ANTITUMOR-ACTIVITY | - |
dc.subject.keywordPlus | CARCINOMA MUCINS | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordPlus | LIGANDS | - |
dc.subject.keywordPlus | ANGIOGENESIS | - |
dc.subject.keywordPlus | PLATELETS | - |
dc.subject.keywordPlus | GROWTH | - |
dc.relation.journalResearchArea | Engineering | - |
dc.relation.journalResearchArea | Materials Science | - |
dc.relation.journalWebOfScienceCategory | Engineering, Biomedical | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Biomaterials | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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