Novel PSEN1 p.Gly417Ala mutation in a Korean patient with early-onset Alzheimer's disease with parkinsonism
- Authors
- Giau, Vo Van; Wang, Min Jeong; Bagyinszky, Eva; Youn, Young Chul; An, Seong Soo A.; Kim, SangYun
- Issue Date
- Dec-2018
- Publisher
- ELSEVIER SCIENCE INC
- Keywords
- Alzheimer's disease; Parkinsonism; PSEN1; p.Gly417Ala
- Citation
- NEUROBIOLOGY OF AGING, v.72, pp 188.e13 - 188.e17
- Journal Title
- NEUROBIOLOGY OF AGING
- Volume
- 72
- Start Page
- 188.e13
- End Page
- 188.e17
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/509
- DOI
- 10.1016/j.neurobiolaging.2018.08.003
- ISSN
- 0197-4580
1558-1497
- Abstract
- Mutations in presenilin 1 (PSEN1) are the most common cause of autosomal dominant Alzheimer's disease. Here, we report a 37-year-old male Korean patient carrying a PSEN1 p.Gly417Ala mutation with exceptionally early and severe presentations, including a wide range of atypical symptoms of rapid cognitive decline with a stooped posture, rigidity, and bradykinesia. Targeted next-generation sequencing of proband revealed a novel nucleotide substitution (c.1250G>C) in exon 12 of PSEN1 gene, altering glycine to alanine at 417 position. Three-dimensional protein structure prediction revealed that the variant may cause perturbations in the 8th transmembrane region, perturbing its functions from the increased hydrophobicity and size of alanine with decreased flexibility. Since several glycine>alanine substitutions in other PSEN1 transmembrane helices revealed aggressive Alzheimer's disease phenotypes, PSEN1 Gly417Ala may share a common pathogenic mechanism. (C) 2018 Elsevier Inc. All rights reserved.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - College of Medicine > College of Medicine > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.