Exosomes derived from human adipose tissue-derived mesenchymal stem cells for the treatment of dupilumab-related facial redness in patients with atopic dermatitis: A report of two cases
- Authors
- Park, Kui Young; Han, Hye Sung; Park, Jae Wan; Kwon, Hyuck Hoon; Park, Gyeong-Hun; Seo, Seong Jun
- Issue Date
- Feb-2022
- Publisher
- WILEY
- Keywords
- atopic dermatitis; dupilumab facial redness; exosome
- Citation
- JOURNAL OF COSMETIC DERMATOLOGY, v.21, no.2, pp 844 - 849
- Pages
- 6
- Journal Title
- JOURNAL OF COSMETIC DERMATOLOGY
- Volume
- 21
- Number
- 2
- Start Page
- 844
- End Page
- 849
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/51420
- DOI
- 10.1111/jocd.14153
- ISSN
- 1473-2130
1473-2165
- Abstract
- Background Atopic dermatitis is a chronic, pruritic, and inflammatory dermatosis that affects approximately 20% of children and 10% of adults worldwide. Dupilumab facial redness is gaining attention as additional cases are coming to light in the medical literature. Objectives and methods Exosomes are nano-sized vesicles that are constantly released by almost all cells. They can travel between cells and transport their cargo (lipids, proteins, and nucleic acids), making them a possible cell-free therapeutic option for various diseases. Herein, we investigated whether topical application of human adipose tissue-derived mesenchymal stem cell-derived exosomes could reduce dupilumab facial redness in patients with severe atopic dermatitis. Results Two patients with atopic dermatitis and refractory dupilumab facial redness were successfully treated with electroporation-assisted topical application of human adipose tissue-derived mesenchymal stem cell-derived exosomes. Six repeated sessions of treatment, with an interval of 1 week between each session, led to marked improvement in erythematous facial lesions. Conclusions We suggest that human adipose tissue-derived mesenchymal stem cell-derived exosomes may serve as an effective agent in the management of dupilumab facial redness. However, further controlled studies with a larger number of patients are necessary to confirm the efficacy and safety of this agent, as well as the optimal treatment protocol.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - College of Medicine > College of Medicine > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/51420)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.