High-resolution three-photon biomedical imaging using doped ZnS nanocrystals
- Authors
- Yu, Jung Ho; Kwon, Seung-Hae; Petrasek, Zdenek; Park, Ok Kyu; Jun, Samuel Woojoo; Shin, Kwangsoo; Choi, Moonkee; Park, Yong Il; Park, Kyeongsoon; Na, Hyon Bin; Lee, Nohyun; Lee, Dong Won; Kim, Jeong Hyun; Schwille, Petra; Hyeon, Taeghwan
- Issue Date
- Apr-2013
- Publisher
- NATURE PUBLISHING GROUP
- Citation
- NATURE MATERIALS, v.12, no.4, pp 359 - 366
- Pages
- 8
- Journal Title
- NATURE MATERIALS
- Volume
- 12
- Number
- 4
- Start Page
- 359
- End Page
- 366
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/51430
- DOI
- 10.1038/NMAT3565
- ISSN
- 1476-1122
1476-4660
- Abstract
- Three-photon excitation is a process that occurs when three photons are simultaneously absorbed within a luminophore for photo-excitation through virtual states. Although the imaging application of this process was proposed decades ago, three-photon biomedical imaging has not been realized yet owing to its intrinsic low quantum efficiency. We herein report on high-resolution in vitro and in vivo imaging by combining three-photon excitation of ZnS nanocrystals and visible emission from Mn2+ dopants. The large three-photon cross-section of the nanocrystals enabled targeted cellular imaging under high spatial resolution, approaching the theoretical limit of three-photon excitation. Owing to the enhanced Stokes shift achieved through nanocrystal doping, the three-photon process was successfully applied to high-resolution in vivo tumour-targeted imaging. Furthermore, the biocompatibility of ZnS nanocrystals offers great potential for clinical applications of three-photon imaging.
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Collections - College of Biotechnology & Natural Resource > Department of Systems Biotechnology > 1. Journal Articles
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