Improved motility in the gastrointestinal tract of a postoperative ileus rat model with ilaprazole
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Geon Min Kim | - |
dc.contributor.author | Hee Ju Sohn | - |
dc.contributor.author | Won Seok Choi | - |
dc.contributor.author | Uy Dong Sohn | - |
dc.date.accessioned | 2021-11-17T01:40:29Z | - |
dc.date.available | 2021-11-17T01:40:29Z | - |
dc.date.issued | 2021-11 | - |
dc.identifier.issn | 1226-4512 | - |
dc.identifier.issn | 2093-3827 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/51502 | - |
dc.description.abstract | Postoperative ileus (POI), a symptom that occurs after abdominal surgery, reduces gastrointestinal motility. Although its mechanism is unclear, POI symptoms are known to be caused by inflammation 6 to 72 h after surgery. As proton pump inhibitors exhibit protective effect against acute inflammation, the purpose of this study was to determine the effect of ilaprazole on a POI rat model. POI was induced in rats by abdominal surgery. Rats were divided into six groups: control: normal rat + 0.5% CMC-Na, vehicle: POI rat + 0.5% CMC-Na, mosapride: POI rat + mosapride 2 mg/kg, ilaprazole 1 mg/kg: POI rat + ilaprazole 1 mg/kg, ilaprazole 3 mg/kg: POI rat + ilaprazole 3 mg/kg, and ilaprazole 10 mg/kg: POI rat + ilaprazole 10 mg/kg. Gastrointestinal motility was confirmed by measuring gastric emptying (GE) and gastrointestinal transit (GIT). In the small intestine, inflammation was confirmed by measuring TNF-α and IL-1β; oxidative stress was confirmed by SOD, GSH, and MDA levels; and histological changes were observed by H&E staining. Based on the findings, GE and GIT were decreased in the vehicle group and improved in the ilaprazole 10 mg/kg group. In the ilaprazole 10 mg/kg group, TNF-α and IL-1β levels were decreased, SOD and GSH levels were increased, and MDA levels were decreased. Histological damage was also reduced in the ilaprazole-treated groups. These findings suggest that ilaprazole prevents the decrease in gastrointestinal motility, a major symptom of postoperative ileus, and reduces inflammation and oxidative stress | - |
dc.format.extent | 9 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | 대한약리학회 | - |
dc.title | Improved motility in the gastrointestinal tract of a postoperative ileus rat model with ilaprazole | - |
dc.title.alternative | Improved motility in the gastrointestinal tract of a postoperative ileus rat model with ilaprazole | - |
dc.type | Article | - |
dc.identifier.doi | 10.4196/kjpp.2021.25.6.507 | - |
dc.identifier.bibliographicCitation | The Korean Journal of Physiology & Pharmacology, v.25, no.6, pp 507 - 515 | - |
dc.identifier.kciid | ART002767488 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000713893500002 | - |
dc.identifier.scopusid | 2-s2.0-85119137047 | - |
dc.citation.endPage | 515 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 507 | - |
dc.citation.title | The Korean Journal of Physiology & Pharmacology | - |
dc.citation.volume | 25 | - |
dc.type.docType | Article | - |
dc.publisher.location | 대한민국 | - |
dc.subject.keywordAuthor | Gastrointestinal tract | - |
dc.subject.keywordAuthor | Ilaprazole | - |
dc.subject.keywordAuthor | Inflammation | - |
dc.subject.keywordAuthor | Postoperative ileus | - |
dc.subject.keywordPlus | INTESTINAL MUSCULARIS | - |
dc.subject.keywordPlus | SUPEROXIDE-DISMUTASE | - |
dc.subject.keywordPlus | MUSCLE DYSFUNCTION | - |
dc.subject.keywordPlus | SMOOTH-MUSCLE | - |
dc.subject.keywordPlus | INFLAMMATION | - |
dc.subject.keywordPlus | ANTIOXIDANT | - |
dc.subject.keywordPlus | MECHANISMS | - |
dc.subject.keywordPlus | EXTRACT | - |
dc.subject.keywordPlus | PROTECTION | - |
dc.subject.keywordPlus | REDUCTION | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalResearchArea | Physiology | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Physiology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
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