Improved motility in the gastrointestinal tract of a postoperative ileus rat model with ilaprazoleImproved motility in the gastrointestinal tract of a postoperative ileus rat model with ilaprazole
- Authors
- Geon Min Kim; Hee Ju Sohn; Won Seok Choi; Uy Dong Sohn
- Issue Date
- Nov-2021
- Publisher
- 대한약리학회
- Keywords
- Gastrointestinal tract; Ilaprazole; Inflammation; Postoperative ileus
- Citation
- The Korean Journal of Physiology & Pharmacology, v.25, no.6, pp 507 - 515
- Pages
- 9
- Journal Title
- The Korean Journal of Physiology & Pharmacology
- Volume
- 25
- Number
- 6
- Start Page
- 507
- End Page
- 515
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/51502
- DOI
- 10.4196/kjpp.2021.25.6.507
- ISSN
- 1226-4512
2093-3827
- Abstract
- Postoperative ileus (POI), a symptom that occurs after abdominal surgery, reduces gastrointestinal motility. Although its mechanism is unclear, POI symptoms are known to be caused by inflammation 6 to 72 h after surgery. As proton pump inhibitors exhibit protective effect against acute inflammation, the purpose of this study was to determine the effect of ilaprazole on a POI rat model. POI was induced in rats by abdominal surgery. Rats were divided into six groups: control: normal rat + 0.5% CMC-Na, vehicle: POI rat + 0.5% CMC-Na, mosapride: POI rat + mosapride 2 mg/kg, ilaprazole 1 mg/kg: POI rat + ilaprazole 1 mg/kg, ilaprazole 3 mg/kg: POI rat + ilaprazole 3 mg/kg, and ilaprazole 10 mg/kg: POI rat + ilaprazole 10 mg/kg. Gastrointestinal motility was confirmed by measuring gastric emptying (GE) and gastrointestinal transit (GIT). In the small intestine, inflammation was confirmed by measuring TNF-α and IL-1β; oxidative stress was confirmed by SOD, GSH, and MDA levels; and histological changes were observed by H&E staining. Based on the findings, GE and GIT were decreased in the vehicle group and improved in the ilaprazole 10 mg/kg group. In the ilaprazole 10 mg/kg group, TNF-α and IL-1β levels were decreased, SOD and GSH levels were increased, and MDA levels were decreased. Histological damage was also reduced in the ilaprazole-treated groups. These findings suggest that ilaprazole prevents the decrease in gastrointestinal motility, a major symptom of postoperative ileus, and reduces inflammation and oxidative stress
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Collections - College of Pharmacy > School of Pharmacy > 1. Journal Articles
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