In Vitro Photodynamic Effects of the Inclusion Nanocomplexes of Glucan and Chlorin e6 on Atherogenic Foam Cells
- Authors
- Ahn, Jae Won; Kim, Jin Hyuk; Park, Kyeongsoon
- Issue Date
- Jan-2021
- Publisher
- MDPI
- Keywords
- beta-glucan; chlorin e6; dectin-1; photodynamic therapy; foam cells
- Citation
- INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v.22, no.1, pp 1 - 12
- Pages
- 12
- Journal Title
- INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Volume
- 22
- Number
- 1
- Start Page
- 1
- End Page
- 12
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/51990
- DOI
- 10.3390/ijms22010177
- ISSN
- 1661-6596
1422-0067
- Abstract
- Macrophage-derived foam cells play critical roles in the initiation and progression of atherosclerosis. Activated macrophages and foam cells are important biomarkers for targeted imaging and inflammatory disease therapy. Macrophages also express the dectin-1 receptor, which specifically recognizes beta-glucan (Glu). Here, we prepared photoactivatable nanoagents (termed Glu/Ce6 nanocomplexes) by encapsulating hydrophobic chlorin e6 (Ce6) within the triple-helix structure of Glu in aqueous condition. Glu/Ce6 nanocomplexes generate singlet oxygen upon laser irradiation. The Glu/Ce6 nanocomplexes were internalized into foam cells and delivered Ce6 molecules into the cytoplasm of foam cells. Upon laser irradiation, they induced significant membrane damage and apoptosis of foam cells. These results suggest that Glu/Ce6 nanocomplexes can be a photoactivatable material for treating atherogenic foam cells.
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Collections - College of Biotechnology & Natural Resource > Department of Systems Biotechnology > 1. Journal Articles
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