Urinary microrna-1913 to microrna-3659 expression ratio as a non-invasive diagnostic biomarker for prostate cancer
DC Field | Value | Language |
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dc.contributor.author | Byun, Y.J. | - |
dc.contributor.author | Piao, X.-M. | - |
dc.contributor.author | Jeong, P. | - |
dc.contributor.author | Kang, H.W. | - |
dc.contributor.author | Seo, S.P. | - |
dc.contributor.author | Moon, S.-K. | - |
dc.contributor.author | Lee, J.-Y. | - |
dc.contributor.author | Choi, Y.H. | - |
dc.contributor.author | Lee, H.Y. | - |
dc.contributor.author | Kim, W.T. | - |
dc.contributor.author | Lee, S.-C. | - |
dc.contributor.author | Cha, E.-J. | - |
dc.contributor.author | Yun, S.J. | - |
dc.contributor.author | Kim, W.-J. | - |
dc.date.accessioned | 2021-12-06T07:40:24Z | - |
dc.date.available | 2021-12-06T07:40:24Z | - |
dc.date.issued | 2021-05 | - |
dc.identifier.issn | 2466-0493 | - |
dc.identifier.issn | 2466-054X | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/52273 | - |
dc.description.abstract | Purpose: MicroRNAs (miRNAs) are small non-coding RNAs and are involved in the development, proliferation, and pathogenesis of prostate cancer (PCa). Urinary miRNAs are promising non-invasive biomarkers for PCa diagnosis because of their stability in urine. Here, we evaluated the diagnostic value of urinary miR-1913 to miR-3659 ratio in PCa patients and benign prostate hyperplasia (BPH) controls. Materials and Methods: Candidate miRNAs were identified from urinary microarray data and tested by real-time PCR. The urinary miR-1913 to miR-3659 expression ratio was selected and tested in 83 urine samples (44 PCa and 39 BPH) to confirm its validity as a non-invasive diagnostic biomarker for PCa. Results: The expression ratio of urinary miR-1913 to miR-3659 was significantly higher in PCa than in BPH (p=0.002) and showed a higher area under the receiver operating characteristic curve than prostate-specific antigen (PSA; 0.821 vs. 0.518) in patients within the PSA gray zone (tPSA: 3–10 ng/mL), with sensitivity of 75.0% and specificity of 78.6% (p=0.003). Conclusions: The urinary miR-1913 to miR-3659 expression ratio was increased in PCa and may serve as a useful supplemental biomarker to PSA for the diagnosis of PCa, particularly in patients within the PSA gray zone. © The Korean Urological Association. | - |
dc.format.extent | 9 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Korean Urological Association | - |
dc.title | Urinary microrna-1913 to microrna-3659 expression ratio as a non-invasive diagnostic biomarker for prostate cancer | - |
dc.type | Article | - |
dc.identifier.doi | 10.4111/icu.20200488 | - |
dc.identifier.bibliographicCitation | Investigative and Clinical Urology, v.62, no.3, pp 340 - 348 | - |
dc.identifier.kciid | ART002714618 | - |
dc.description.isOpenAccess | Y | - |
dc.identifier.wosid | 000652239000014 | - |
dc.identifier.scopusid | 2-s2.0-85105375394 | - |
dc.citation.endPage | 348 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 340 | - |
dc.citation.title | Investigative and Clinical Urology | - |
dc.citation.volume | 62 | - |
dc.type.docType | Article | - |
dc.publisher.location | 대한민국 | - |
dc.subject.keywordAuthor | Biomarkers | - |
dc.subject.keywordAuthor | Diagnosis | - |
dc.subject.keywordAuthor | Gene expression | - |
dc.subject.keywordAuthor | MicroRNA | - |
dc.subject.keywordAuthor | Prostate neoplasms | - |
dc.subject.keywordPlus | MIRNAS | - |
dc.subject.keywordPlus | TISSUE | - |
dc.relation.journalResearchArea | Urology & Nephrology | - |
dc.relation.journalWebOfScienceCategory | Urology & Nephrology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
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