Urinary microrna-1913 to microrna-3659 expression ratio as a non-invasive diagnostic biomarker for prostate canceropen access
- Authors
- Byun, Y.J.; Piao, X.-M.; Jeong, P.; Kang, H.W.; Seo, S.P.; Moon, S.-K.; Lee, J.-Y.; Choi, Y.H.; Lee, H.Y.; Kim, W.T.; Lee, S.-C.; Cha, E.-J.; Yun, S.J.; Kim, W.-J.
- Issue Date
- May-2021
- Publisher
- Korean Urological Association
- Keywords
- Biomarkers; Diagnosis; Gene expression; MicroRNA; Prostate neoplasms
- Citation
- Investigative and Clinical Urology, v.62, no.3, pp 340 - 348
- Pages
- 9
- Journal Title
- Investigative and Clinical Urology
- Volume
- 62
- Number
- 3
- Start Page
- 340
- End Page
- 348
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/52273
- DOI
- 10.4111/icu.20200488
- ISSN
- 2466-0493
2466-054X
- Abstract
- Purpose: MicroRNAs (miRNAs) are small non-coding RNAs and are involved in the development, proliferation, and pathogenesis of prostate cancer (PCa). Urinary miRNAs are promising non-invasive biomarkers for PCa diagnosis because of their stability in urine. Here, we evaluated the diagnostic value of urinary miR-1913 to miR-3659 ratio in PCa patients and benign prostate hyperplasia (BPH) controls. Materials and Methods: Candidate miRNAs were identified from urinary microarray data and tested by real-time PCR. The urinary miR-1913 to miR-3659 expression ratio was selected and tested in 83 urine samples (44 PCa and 39 BPH) to confirm its validity as a non-invasive diagnostic biomarker for PCa. Results: The expression ratio of urinary miR-1913 to miR-3659 was significantly higher in PCa than in BPH (p=0.002) and showed a higher area under the receiver operating characteristic curve than prostate-specific antigen (PSA; 0.821 vs. 0.518) in patients within the PSA gray zone (tPSA: 3–10 ng/mL), with sensitivity of 75.0% and specificity of 78.6% (p=0.003). Conclusions: The urinary miR-1913 to miR-3659 expression ratio was increased in PCa and may serve as a useful supplemental biomarker to PSA for the diagnosis of PCa, particularly in patients within the PSA gray zone. © The Korean Urological Association.
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