Sustainable radical approaches for cross electrophile coupling to synthesize trifluoromethyl- and allyl-substituted tert-alcohols
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Ashraf, Muhammad Awais | - |
dc.contributor.author | Lee, Yunjeong | - |
dc.contributor.author | Iqbal, Naila | - |
dc.contributor.author | Iqbal, Naeem | - |
dc.contributor.author | Cho, Eun Jin | - |
dc.date.accessioned | 2021-12-09T02:40:38Z | - |
dc.date.available | 2021-12-09T02:40:38Z | - |
dc.date.issued | 2021-12 | - |
dc.identifier.issn | 2589-0042 | - |
dc.identifier.issn | 2589-0042 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/52392 | - |
dc.description.abstract | Trifluoromethylated molecules have gained privileged recognition among the medicinal and pharmaceutical chemists. Sustainable photoredox- and electrochemical processes were employed to facilitate the relatively less explored radical cross-electrophile coupling to access trifluoromethyl- and allyl-substituted tert-alcohols. Reactions proceed through trifluoromethyl ketyl radical and allyl radical intermediates, which undergo challenging radical-radical cross-coupling. The developed transformations are mild and chemo-selective to give cross-coupled products and deliver a wide range of valuable trifluoromethyl- and allyl-containing tertiary alcohols. Both processes can also be applied for the synthesis of amine variant containing trifluoromethyl and allyl moiety, which is considered as amide bioisostere. © 2021 The Author(s) | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Elsevier Inc. | - |
dc.title | Sustainable radical approaches for cross electrophile coupling to synthesize trifluoromethyl- and allyl-substituted tert-alcohols | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.isci.2021.103388 | - |
dc.identifier.bibliographicCitation | iScience, v.24, no.12 | - |
dc.description.isOpenAccess | Y | - |
dc.identifier.wosid | 000740249400005 | - |
dc.identifier.scopusid | 2-s2.0-85119998541 | - |
dc.citation.number | 12 | - |
dc.citation.title | iScience | - |
dc.citation.volume | 24 | - |
dc.type.docType | Article | - |
dc.publisher.location | 미국 | - |
dc.subject.keywordAuthor | Chemistry | - |
dc.subject.keywordAuthor | Green chemistry | - |
dc.subject.keywordAuthor | Organic chemistry | - |
dc.subject.keywordAuthor | Organic chemistry methods | - |
dc.subject.keywordPlus | INDIUM-MEDIATED ALLYLATION | - |
dc.subject.keywordPlus | ELECTROCHEMICAL GENERATION | - |
dc.subject.keywordPlus | KETONES | - |
dc.subject.keywordPlus | ALDEHYDES | - |
dc.subject.keywordPlus | REAGENTS | - |
dc.subject.keywordPlus | CATALYSIS | - |
dc.subject.keywordPlus | FLUORINE | - |
dc.subject.keywordPlus | ACCESS | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | ANNULATION | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
84, Heukseok-ro, Dongjak-gu, Seoul, Republic of Korea (06974)02-820-6194
COPYRIGHT 2019 Chung-Ang University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.