Sustainable radical approaches for cross electrophile coupling to synthesize trifluoromethyl- and allyl-substituted tert-alcoholsopen access
- Authors
- Ashraf, Muhammad Awais; Lee, Yunjeong; Iqbal, Naila; Iqbal, Naeem; Cho, Eun Jin
- Issue Date
- Dec-2021
- Publisher
- Elsevier Inc.
- Keywords
- Chemistry; Green chemistry; Organic chemistry; Organic chemistry methods
- Citation
- iScience, v.24, no.12
- Journal Title
- iScience
- Volume
- 24
- Number
- 12
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/52392
- DOI
- 10.1016/j.isci.2021.103388
- ISSN
- 2589-0042
2589-0042
- Abstract
- Trifluoromethylated molecules have gained privileged recognition among the medicinal and pharmaceutical chemists. Sustainable photoredox- and electrochemical processes were employed to facilitate the relatively less explored radical cross-electrophile coupling to access trifluoromethyl- and allyl-substituted tert-alcohols. Reactions proceed through trifluoromethyl ketyl radical and allyl radical intermediates, which undergo challenging radical-radical cross-coupling. The developed transformations are mild and chemo-selective to give cross-coupled products and deliver a wide range of valuable trifluoromethyl- and allyl-containing tertiary alcohols. Both processes can also be applied for the synthesis of amine variant containing trifluoromethyl and allyl moiety, which is considered as amide bioisostere. © 2021 The Author(s)
- Files in This Item
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