Genetic association of polymorphisms in porcine RGS16 with porcine circovirus viral load in naturally infected Yorkshire pigsopen access
- Authors
- Lee, Seung-Hoon; Lim, Kyu-Sang; Hong, Ki-Chang; Kim, Jun-Mo
- Issue Date
- 2021
- Publisher
- 한국축산학회
- Keywords
- PCV2; Viral load; RGS16; Single nucleotide polymorphism; Pig
- Citation
- 한국축산학회지, v.63, no.6, pp 1223 - 1231
- Pages
- 9
- Journal Title
- 한국축산학회지
- Volume
- 63
- Number
- 6
- Start Page
- 1223
- End Page
- 1231
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/52435
- DOI
- 10.5187/jast.2021.e105
- ISSN
- 2672-0191
2055-0391
- Abstract
- Regulator of G protein signaling 16 (RGS16) is known to be associated with porcine circovirus type 2 (PCV2). PCV2 associated disease (PCVAD) is a serious problem in the swine industry. The representative symptoms of PCVAD are high viral titer proliferation and decreased average daily gain. In this study, we identified single nucleotide polymorphisms (SNPs) in the RGS16 region, including the upstream region. Of the 22 identified SNPs, rs332913874, rs326071195, and rs318298586 were genotyped in 142 Yorkshire pigs. These SNPs were significantly associated with the PCV2 viral load. Moreover, the haplotype combination was also related to the PCV2 viral load. The haplotype and diplotype analysis also had a significant difference with the PCV2 viral load. Taken together, our results suggest that RGS16 SNPs considerably affect the PCV2 viral load.
- Files in This Item
-
- Appears in
Collections - ETC > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/52435)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.