Investigating the in vitro osteogenic properties of the inclusion nanocarrier of icariin with beta-cyclodextrin-alginate
DC Field | Value | Language |
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dc.contributor.author | Choi, S. | - |
dc.contributor.author | Lee, Y.S. | - |
dc.contributor.author | Jo, H.-S. | - |
dc.contributor.author | Jeong, W.K. | - |
dc.contributor.author | Kim, H.-J. | - |
dc.contributor.author | Song, M.H. | - |
dc.contributor.author | Park, Kyeongsoon | - |
dc.contributor.author | Kim, S.E. | - |
dc.date.accessioned | 2022-01-04T04:40:18Z | - |
dc.date.available | 2022-01-04T04:40:18Z | - |
dc.date.issued | 2020-06 | - |
dc.identifier.issn | 2076-3417 | - |
dc.identifier.issn | 2076-3417 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/52881 | - |
dc.description.abstract | In this study, we created an inclusion nanocarrier of icariin (ICA) and β-cyclodextrin-alginate conjugate (ICA/β-CD-ALG) and determined its in vitro osteogenic ability on MC3T3-E1 cells. The morphological shape of the prepared β-CD-ALG with or without ICA was nano-sized and round. The use of β-CD-ALG achieved a sustained ICA release for up to 7 days. In vitro studies found that ICA/β-CD-ALG had a greater potential in osteogenesis on MC3T3-E1 cells compared to β-CD-ALG by exhibiting both higher alkaline phosphatase levels and the amount of calcium deposits. Moreover, ICA/β-CD-ALG greatly increased the levels of osteogenesis markers including osteocalcin (OCN) and osteopontin (OPN). Our results suggest that ICA/β-CD-ALG plays a significant role in cellular osteogenic activity. © 2020 by the authors. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | MDPI AG | - |
dc.title | Investigating the in vitro osteogenic properties of the inclusion nanocarrier of icariin with beta-cyclodextrin-alginate | - |
dc.type | Article | - |
dc.identifier.doi | 10.3390/app10124137 | - |
dc.identifier.bibliographicCitation | Applied Sciences (Switzerland), v.10, no.12 | - |
dc.description.isOpenAccess | Y | - |
dc.identifier.wosid | 000554606600001 | - |
dc.identifier.scopusid | 2-s2.0-85087797498 | - |
dc.citation.number | 12 | - |
dc.citation.title | Applied Sciences (Switzerland) | - |
dc.citation.volume | 10 | - |
dc.type.docType | Article | - |
dc.publisher.location | 스위스 | - |
dc.subject.keywordAuthor | Drug delivery | - |
dc.subject.keywordAuthor | Icariin | - |
dc.subject.keywordAuthor | MC3T3 | - |
dc.subject.keywordAuthor | Osteogenic activity | - |
dc.subject.keywordAuthor | β-cyclodextrin-alginate | - |
dc.subject.keywordPlus | STEM-CELLS | - |
dc.subject.keywordPlus | DIFFERENTIATION | - |
dc.subject.keywordPlus | PROLIFERATION | - |
dc.subject.keywordPlus | COMPOUND | - |
dc.subject.keywordPlus | VIVO | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalResearchArea | Engineering | - |
dc.relation.journalResearchArea | Materials Science | - |
dc.relation.journalResearchArea | Physics | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.relation.journalWebOfScienceCategory | Engineering, Multidisciplinary | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Multidisciplinary | - |
dc.relation.journalWebOfScienceCategory | Physics, Applied | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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