Investigating the in vitro osteogenic properties of the inclusion nanocarrier of icariin with beta-cyclodextrin-alginateopen access
- Authors
- Choi, S.; Lee, Y.S.; Jo, H.-S.; Jeong, W.K.; Kim, H.-J.; Song, M.H.; Park, Kyeongsoon; Kim, S.E.
- Issue Date
- Jun-2020
- Publisher
- MDPI AG
- Keywords
- Drug delivery; Icariin; MC3T3; Osteogenic activity; β-cyclodextrin-alginate
- Citation
- Applied Sciences (Switzerland), v.10, no.12
- Journal Title
- Applied Sciences (Switzerland)
- Volume
- 10
- Number
- 12
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/52881
- DOI
- 10.3390/app10124137
- ISSN
- 2076-3417
2076-3417
- Abstract
- In this study, we created an inclusion nanocarrier of icariin (ICA) and β-cyclodextrin-alginate conjugate (ICA/β-CD-ALG) and determined its in vitro osteogenic ability on MC3T3-E1 cells. The morphological shape of the prepared β-CD-ALG with or without ICA was nano-sized and round. The use of β-CD-ALG achieved a sustained ICA release for up to 7 days. In vitro studies found that ICA/β-CD-ALG had a greater potential in osteogenesis on MC3T3-E1 cells compared to β-CD-ALG by exhibiting both higher alkaline phosphatase levels and the amount of calcium deposits. Moreover, ICA/β-CD-ALG greatly increased the levels of osteogenesis markers including osteocalcin (OCN) and osteopontin (OPN). Our results suggest that ICA/β-CD-ALG plays a significant role in cellular osteogenic activity. © 2020 by the authors.
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