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Gold nanoparticle-DNA aptamer-assisted delivery of antimicrobial peptide effectively inhibits Acinetobacter baumannii infection in miceopen access
- Authors
- Park, Jaeyeong; Shin, Eunkyoung; Yeom, Ji-Hyun; Choi, Younkyung; Joo, Minju; Lee, Minho; Kim, Je Hyeong; Bae, Jeehyeon; Lee, Kangseok
- Issue Date
- Jan-2022
- Publisher
- 한국미생물학회
- Keywords
- Acinetobacter baumannii; antimicrobial peptide; gold nanoparticle; multidrug-resistant bacteria
- Citation
- The Journal of Microbiology, v.60, no.1, pp 128 - 136
- Pages
- 9
- Journal Title
- The Journal of Microbiology
- Volume
- 60
- Number
- 1
- Start Page
- 128
- End Page
- 136
- ISSN
- 1225-8873
1976-3794
- Abstract
- Acinetobacter baumannii causes multidrug resistance, leading to fatal infections in humans. In this study, we showed that Lys AB2 P3-His–a hexahistidine-tagged form of an antimicrobial peptide (AMP) loaded onto DNA aptamer-functionalized gold nanoparticles (AuNP-Apt)–can effectively inhibit A. baumannii infection in mice. When A. baumannii-infected mice were intraperitoneally injected with AuNP-Apt loaded with Lys AB2 P3-His, a marked reduction in A. baumannii colonization was observed in the mouse organs, leading to prominently increased survival time and rate of the mice compared to those of the control mice treated with AuNP-Apt or Lys AB2 P3-His only. This study shows that AMPs loaded onto AuNP-Apt could be an effective therapeutic tool against infections caused by multidrug-resistant pathogenic bacteria in humans.
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