Repositioning medication for cardiovascular and cerebrovascular disease to delay the onset and prevent progression of Alzheimer's disease
- Authors
- Lee, Heeyoung; Kim, EunYoung
- Issue Date
- Sep-2020
- Publisher
- PHARMACEUTICAL SOC KOREA
- Keywords
- Alzheimer's disease; Cardiovascular disease; Cerebrovascular disease; Pharmacotherapeutic implications; Drug repositioning
- Citation
- ARCHIVES OF PHARMACAL RESEARCH, v.43, no.9, pp 932 - 960
- Pages
- 29
- Journal Title
- ARCHIVES OF PHARMACAL RESEARCH
- Volume
- 43
- Number
- 9
- Start Page
- 932
- End Page
- 960
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/53395
- DOI
- 10.1007/s12272-020-01268-5
- ISSN
- 0253-6269
1976-3786
- Abstract
- Alzheimer's disease (AD) is a complex, progressive, neurodegenerative disorder. As with other common chronic diseases, multiple risk factors contribute to the onset and progression of AD. Many researchers have evaluated the epidemiologic and pathophysiological association between AD, cardiovascular diseases (CVDs), and cerebrovascular diseases (CBVDs), including commonly reported risk factors such as diabetes, hypertension, and dyslipidemia. Relevant therapies of CVDs/CBVDs for the attenuation of AD have also been empirically investigated. Considering the challenges of new drug development, in terms of cost and time, multifactorial approaches such as therapeutic repositioning of CVD/CBVD medication should be explored to delay the onset and progression of AD. Thus, in this review, we discuss our current understanding of the association between cardiovascular risk factors and AD, as revealed by clinical and non-clinical studies, as well as the therapeutic implications of CVD/CBVD medication that may attenuate AD. Furthermore, we discuss future directions by evaluating ongoing trials in the field.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - College of Pharmacy > School of Pharmacy > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/53395)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.