Clinical Features, Epidemiology, and Climatic Impact of Genotype-specific Human Metapneumovirus Infections: Long-term Surveillance of Hospitalized Patients in South Korea
- Authors
- Lim, Yong Kwan; Kweon, Oh Joo; Kim, Hye Ryoun; Kim, Tae-Hyoung; Lee, Mi-Kyung
- Issue Date
- Jun-2020
- Publisher
- OXFORD UNIV PRESS INC
- Keywords
- human metapneumovirus; genotype; acute respiratory tract infection; epidemiology; meteorological factors
- Citation
- CLINICAL INFECTIOUS DISEASES, v.70, no.12, pp 2683 - 2694
- Pages
- 12
- Journal Title
- CLINICAL INFECTIOUS DISEASES
- Volume
- 70
- Number
- 12
- Start Page
- 2683
- End Page
- 2694
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/53503
- DOI
- 10.1093/cid/ciz697
- ISSN
- 1058-4838
1537-6591
- Abstract
- Background. Human metapneumovirus (hMPV) commonly causes upper and lower respiratory tract infections. Here, we performed long-term retrospective surveillance of hMPV infection among patients hospitalized in South Korea between 2007 and 2016 and investigated seasonal dynamics and clinical characteristics associated with each virus subtype/genotype. Methods. Patient specimens were tested for hMPV and other respiratory viruses by commercial molecular assays. Medical records of hMPV-positive patients were reviewed, and hMPV subtype/genotype analysis was performed. We also collected meteorological data and analyzed relationships with hMPV activity. Results. Of 23 694 specimens, 1275 (5.4%) were positive; among them, 94.0% were classified into 5 subtypes (A1, A2a, A2b, B1, and B2). Some clinical manifestations differed according to hMPV genotype; however, there was no correlation between hMPV subtype and clinical outcome. Viral activity peaked at 13-20 weeks (April and May) and was associated with climate-specific factors, including temperature, relative humidity, diurnal temperature variation, wind speed, and sunshine duration. Conclusions. This large-scale, 10-year study provides valuable information about the clinical characteristics associated with hMPV subtypes and climate factors contributing to virus transmission.
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