Alternative chromatographic method for the assay test of terbutaline and salbutamol using ionic liquid assisted aqueous mobile phaseAlternative chromatographic method for the assay test of terbutaline and salbutamol using ionic liquid assisted aqueous mobile phase
- Authors
- Mai, Xuan-Lan; Choi, Yusung; Truong, Quoc-Ky; Nguyen, Thi-Ngoc-Van; Han, Sang Beom; Kim, Kyeong Ho
- Issue Date
- Aug-2020
- Publisher
- 한국분석과학회
- Keywords
- ionic liquid; salbutamol; terbutaline; reverse phase HPLC 1. Introduction Liquid chromatography (LC)-based researches generate about more than 34 million L of organic solvent waste annually.1 To reduce the negative impacts of the organic solvent waste from laboratories to the environment; green chemistry studies have become trending in analytical sciences. The green analytical chemistry approaches include the miniaturization of the sample preparation techniques and determination devices
- Citation
- 분석과학, v.33, no.4, pp 169 - 176
- Pages
- 8
- Journal Title
- 분석과학
- Volume
- 33
- Number
- 4
- Start Page
- 169
- End Page
- 176
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/53527
- DOI
- 10.5806/AST.2020.33.4.169
- ISSN
- 1225-0163
2288-8985
- Abstract
- Separation of basic compounds using reverse phase chromatography on a silica-based stationary phase represents a major challenge, because of the interaction between the cationic sites of the basic compounds with the anionic silanols of the stationary phase. This study presents a simple, reliable, and organic solvent - free liquid chromatographic method for the determination of terbutaline and salbutamol, in which a room temperature ionic liquid (RTIL) is used as mobile phase additive. We investigated various mobile phase parameters affecting the retention of the two compounds, such as types and concentration of RTILs and, pH of the mobile phase were investigated. The developed method was validated according to International Conference on Harmonization (ICH) guidelines and successfully applied effectively to determine salbutamol sulfate in pharmaceutical preparations.
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Collections - College of Pharmacy > School of Pharmacy > 1. Journal Articles
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