Long-term patient-reported outcomes following laparoscopic cholecystectomy: A prospective multicenter observational studyopen access
- Authors
- Han, In Woong; Lee, Hyeon Kook; Park, Dae Joon; Choi, Yoo Shin; Lee, Seung Eun; Kim, Hongbeom; Kwon, Wooil; Jang, Jin-Young; Lee, Huisong; Heo, Jin Seok
- Issue Date
- Aug-2020
- Publisher
- NLM (Medline)
- Keywords
- laparoscopic cholecystectomy; patient-reported outcome; quality of life
- Citation
- Medicine, v.99, no.35
- Journal Title
- Medicine
- Volume
- 99
- Number
- 35
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/53633
- DOI
- 10.1097/MD.0000000000021683
- ISSN
- 0025-7974
1536-5964
- Abstract
- Several studies have reported short-term results for post-cholecystectomy symptoms and quality of life (QoL). However, reports on long-term results are still limited. This study aimed to identify risk factors affecting short- and long-term patient-reported outcome (PRO) following laparoscopic cholecystectomy.From 2016 to 2017, a total of 476 patients from 5 institutions were enrolled. PRO was examined using the Numeric Rating Scale (NRS) pain score and the Gastrointestinal (GI) QoL Index questionnaire at postoperative 1 month and 1 year.Most of patients recovered well at postoperative 1 year compared to postoperative 1 month for the NRS pain score, QoL score, and GI symptoms. A high operative difficulty score (HR 1.740, P = .031) and pathology of acute or complicated cholecystitis (HR 1.524, P = .048) were identified as independent risk factors for high NRS pain scores at postoperative 1 month. Similarly, female sex (HR 1.571, P = .003) at postoperative 1 month and postoperative complications (HR 5.567, P = .001) at postoperative 1 year were independent risk factors for a low QoL. Also, age above 50 (HR 1.842, P = .001), female sex (HR 1.531, P = .006), and preoperative gallbladder drainage (HR 3.086, P = .001) were identified as independent risk factors for GI symptoms at postoperative 1 month.Most patients showed improved long-term PRO measurement in terms of pain, QoL, and GI symptoms. There were no independent risk factors for long-term postoperative pain and GI symptoms. However, postoperative complications were identified to affect QoL adversely at postoperative 1 year. Careful and long-term follow up is thus necessary for patients who experienced postoperative complications.
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