The role of histogram analysis of grayscale sonograms to differentiate thyroid nodules identified by F-18-FDG PET-CT
- Authors
- Park, Ko Woon; Shin, Jung Hee; Hahn, Soo Yeon; Kim, Jae-Hun; Lim, Yaeji; Choi, Joon Young
- Issue Date
- Nov-2020
- Publisher
- LIPPINCOTT WILLIAMS & WILKINS
- Keywords
- histogram; metastasis; PET; thyroid nodule; ultrasonography
- Citation
- MEDICINE, v.99, no.48, pp e23252
- Journal Title
- MEDICINE
- Volume
- 99
- Number
- 48
- Start Page
- e23252
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/54026
- DOI
- 10.1097/MD.0000000000023252
- ISSN
- 0025-7974
1536-5964
- Abstract
- The role of histogram based on ultrasound (US) images for thyroid nodules found in fluorine-18 fluorodeoxyglucose (18F-FDG) Positron Emission Tomography/Computed Tomography (PET-CT) is unknown. We aimed to assess whether histogram analysis using gray scale US could differentiate thyroid nodules detected by PET-CT. In this study, 71 thyroid nodules >= 1 cm were identified in 71 patients by conducting 18F-FDG PET-CT, from January 2010 to June 2013. Subsequently, either grayscale US-guided fine needle aspirations or core needle biopsies were performed on each patient. Each grayscale US feature was categorized according to the Korean Thyroid Imaging Reporting and Data System (K-TIRADS). Histogram parameters (skewness, kurtosis, intensity, uniformity, and entropy) were extracted from the grayscale US images followed by statistical analysis using the Chi-Squared or Mann-Whitney U tests. The 71 nodules comprised 30 (42.3%) benign nodules, 30 (42.3%) primary thyroid malignancies, and 11 (15.4%) metastatic lesions. Tumor size, US findings, and histogram parameters were significantly different between the benign and malignant thyroid nodules (P = .011, P = .000, and P < .02, respectively). A comparison showed that parallel orientation and an absence of calcifications were found more frequently in metastatic thyroid nodules than in primary thyroid malignancies (P = .04, P < .000, respectively). However, histogram parameters and K-TIRADS were not significantly different between primary thyroid malignancies and metastatic lesions. There is a limit to replacing cytopathological confirmation with texture analysis for the differentiation of thyroid nodules detected by PET-CT. Therefore, cytopathological confirmation of nodules appearing malignant on US images cannot be avoided for an ultimate diagnosis of metastasis.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - Graduate School > ETC > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/54026)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.