Anti-viral CD8+T cell responses are impaired by endogenous n-3 polyunsaturated fatty acids
DC Field | Value | Language |
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dc.contributor.author | Seo, Young-Jin | - |
dc.contributor.author | Kim, Seyoung | - |
dc.contributor.author | Cho, Yong-Bin | - |
dc.contributor.author | Kang, Kyung-Won | - |
dc.contributor.author | Lee, Sang-Myeong | - |
dc.date.accessioned | 2022-01-24T03:43:04Z | - |
dc.date.available | 2022-01-24T03:43:04Z | - |
dc.date.issued | 2019-05 | - |
dc.identifier.issn | 0022-1767 | - |
dc.identifier.issn | 1550-6606 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/54187 | - |
dc.description.abstract | Omega-3 (n-3) polyunsaturated fatty acids (PUFAs) have been known to exert anti-inflammatory effects on various inflammatory diseases. However, its role in CD8+ T cell responses against an acute viral infection has not been well elucidated yet. To determine the role of n-3 PUFAs in anti-viral CD8+ T cell responses, we used FAT-1 transgenic mice that are able to convert n-6 PUFAs to n-3 PUFAs. The FAT-1 mice or mice orally administrated with n-3 PFUAs exhibited a significant reduction of anti-viral CD8+ T cell responses against an acute strain of lymphocytic choriomeningitis virus (LCMV). When LCMV-specific P14 CD8+ T cells carrying fat-1 gene (P14/FAT-1) were adoptively transferred into mice that were subsequently infected with LCMV, expansion of the cells was substantially suppressed. Similarly, when P14/FAT-1 cells were stimulated with LCMV gp33 peptide in vitro, their expansion was significantly reduced as compared to P14 cells. Collectively, our results indicate that n-3 PUFAs attenuate anti-viral CD8+ T cell responses against acute viral infection. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | AMER ASSOC IMMUNOLOGISTS | - |
dc.title | Anti-viral CD8+T cell responses are impaired by endogenous n-3 polyunsaturated fatty acids | - |
dc.type | Article | - |
dc.identifier.doi | 10.4049/jimmunol.202.Supp.56.22 | - |
dc.identifier.bibliographicCitation | JOURNAL OF IMMUNOLOGY, v.202, no.sup.1 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000524982500091 | - |
dc.citation.number | sup.1 | - |
dc.citation.title | JOURNAL OF IMMUNOLOGY | - |
dc.citation.volume | 202 | - |
dc.type.docType | Meeting Abstract | - |
dc.publisher.location | 미국 | - |
dc.relation.journalResearchArea | Immunology | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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