Anti-viral CD8+T cell responses are impaired by endogenous n-3 polyunsaturated fatty acids
- Authors
- Seo, Young-Jin; Kim, Seyoung; Cho, Yong-Bin; Kang, Kyung-Won; Lee, Sang-Myeong
- Issue Date
- May-2019
- Publisher
- AMER ASSOC IMMUNOLOGISTS
- Citation
- JOURNAL OF IMMUNOLOGY, v.202, no.sup.1
- Journal Title
- JOURNAL OF IMMUNOLOGY
- Volume
- 202
- Number
- sup.1
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/54187
- DOI
- 10.4049/jimmunol.202.Supp.56.22
- ISSN
- 0022-1767
1550-6606
- Abstract
- Omega-3 (n-3) polyunsaturated fatty acids (PUFAs) have been known to exert anti-inflammatory effects on various inflammatory diseases. However, its role in CD8+ T cell responses against an acute viral infection has not been well elucidated yet. To determine the role of n-3 PUFAs in anti-viral CD8+ T cell responses, we used FAT-1 transgenic mice that are able to convert n-6 PUFAs to n-3 PUFAs. The FAT-1 mice or mice orally administrated with n-3 PFUAs exhibited a significant reduction of anti-viral CD8+ T cell responses against an acute strain of lymphocytic choriomeningitis virus (LCMV). When LCMV-specific P14 CD8+ T cells carrying fat-1 gene (P14/FAT-1) were adoptively transferred into mice that were subsequently infected with LCMV, expansion of the cells was substantially suppressed. Similarly, when P14/FAT-1 cells were stimulated with LCMV gp33 peptide in vitro, their expansion was significantly reduced as compared to P14 cells. Collectively, our results indicate that n-3 PUFAs attenuate anti-viral CD8+ T cell responses against acute viral infection.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - College of Natural Sciences > Department of Life Science > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/54187)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.