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Comparative Proteomic Analysis for a Putative Pyridoxal Phosphate-Depen- dent Aminotransferase Required for Virulence in Acidovorax citrulliopen access

Authors
Lee, JongchanHeo, LynnHan, Sang-Wook
Issue Date
Dec-2021
Publisher
한국식물병리학회
Keywords
Acidovorax citrulli; proteomics; pyridoxal phosphate-dependent aminotransferase
Citation
The Plant Pathology Journal, v.37, no.6, pp 673 - 680
Pages
8
Journal Title
The Plant Pathology Journal
Volume
37
Number
6
Start Page
673
End Page
680
URI
https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/54503
DOI
10.5423/PPJ.NT.09.2021.0139
ISSN
1598-2254
2093-9280
Abstract
Acidovorax citrulli (Ac) is the causative agent of bacte- rial fruit blotch disease in watermelon. Since resistant cultivars have not yet been developed, the virulence factors/mechanisms of Ac need to be characterized. This study reports the functions of a putative pyridoxal phosphate-dependent aminotransferase (PpdaAc) that transfers amino groups to its substrates and uses pyridoxal phosphate as a coenzyme. It was observed that a ppdaAc knockout mutant had a significantly reduced virulence in watermelon when introduced via germinated-seed inoculation as well as leaf infiltration. Comparative proteomic analysis predicted the cellular mechanisms related to PpdaAc. Apart from causing virulence, the PpdaAc may have significant roles in energy production, cell membrane, motility, chemo- taxis, post-translational modifications, and iron-related mechanisms. Therefore, it is postulated that PpdaAc may possess pleiotropic effects. These results provide new insights into the functions of a previously unidenti- fied PpdaAc in Ac.
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Han, Sang-Wook
생명공학대학 (식물생명공학)
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