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The Antibiotic Susceptibility of Escherichia coli from Community-Acquired Uncomplicated Urinary Tract Infection: A Focused on Fosfomycin

Authors
최현섭이승주장인호김태형정홍정재민이상돈정재흥김기호민승기나용길윤하나유호송이미경이선주
Issue Date
Aug-2017
Publisher
대한요로생식기감염학회
Keywords
Drug resistance; Fosfomycin; Urinary tract infections
Citation
Urogenital Tract Infection, v.12, no.2, pp 77 - 81
Pages
5
Journal Title
Urogenital Tract Infection
Volume
12
Number
2
Start Page
77
End Page
81
URI
https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/5480
DOI
10.14777/uti.2017.12.2.77
ISSN
2465-8243
2465-8510
Abstract
Purpose: To assess the antibiotic susceptibility of Escherichia coli from commu-nity-acquired uncomplicated urinary tract infection (UTI).Materials and Methods: Between August and December of 2015, confirmed cases of E. coli as a pathogen of community-acquired uncomplicated UTI were collected and assessed for antibiotic susceptibility in 10 designated hospitals. Additional fosfomycin susceptibility test was performed by a central laboratory using the disk diffusion method.Results: A total of 347 E. coli isolates were collected from urine samples of community-acquired uncomplicated UTIs patients. The susceptibility rates of antibiotics were as follows: amikacin 100.0% (347), imipenem 100.0% (347), ciprofloxacin 57.1% (198), cefotaxime 74.9% (260), ampicillin 30.0% (104), trimethoprim/sulfamethoxazole 66.9% (232), and fosfomycin 98.0% (340). All fosfomycin-resistant E. coli isolates were extended-spectrum -lactamase (ESBL)-producing. In 85 cases of ESBL-producing E. coli, the fosfomycin susceptibility rate was 91.8% (78/85).Conclusions: Fosfomycin may be a useful option for the treatment of community-acquired uncomplicated UTIs. Further studies evaluating the role of fosfomycin in the treatment of UTIs and its clinical efficacy are necessary.
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