The Antibiotic Susceptibility of Escherichia coli from Community-Acquired Uncomplicated Urinary Tract Infection: A Focused on Fosfomycin
- Authors
- 최현섭; 이승주; 장인호; 김태형; 정홍; 정재민; 이상돈; 정재흥; 김기호; 민승기; 나용길; 윤하나; 유호송; 이미경; 이선주
- Issue Date
- Aug-2017
- Publisher
- 대한요로생식기감염학회
- Keywords
- Drug resistance; Fosfomycin; Urinary tract infections
- Citation
- Urogenital Tract Infection, v.12, no.2, pp 77 - 81
- Pages
- 5
- Journal Title
- Urogenital Tract Infection
- Volume
- 12
- Number
- 2
- Start Page
- 77
- End Page
- 81
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/5480
- DOI
- 10.14777/uti.2017.12.2.77
- ISSN
- 2465-8243
2465-8510
- Abstract
- Purpose: To assess the antibiotic susceptibility of Escherichia coli from commu-nity-acquired uncomplicated urinary tract infection (UTI).Materials and Methods: Between August and December of 2015, confirmed cases of E. coli as a pathogen of community-acquired uncomplicated UTI were collected and assessed for antibiotic susceptibility in 10 designated hospitals. Additional fosfomycin susceptibility test was performed by a central laboratory using the disk diffusion method.Results: A total of 347 E. coli isolates were collected from urine samples of community-acquired uncomplicated UTIs patients. The susceptibility rates of antibiotics were as follows: amikacin 100.0% (347), imipenem 100.0% (347), ciprofloxacin 57.1% (198), cefotaxime 74.9% (260), ampicillin 30.0% (104), trimethoprim/sulfamethoxazole 66.9% (232), and fosfomycin 98.0% (340). All fosfomycin-resistant E. coli isolates were extended-spectrum -lactamase (ESBL)-producing. In 85 cases of ESBL-producing E. coli, the fosfomycin susceptibility rate was 91.8% (78/85).Conclusions: Fosfomycin may be a useful option for the treatment of community-acquired uncomplicated UTIs. Further studies evaluating the role of fosfomycin in the treatment of UTIs and its clinical efficacy are necessary.
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