Early recombinant human epidermal growth factor treatment recovers the irradiation-induced decrease of Na plus absorption prior to the definite histological mucositis
- Authors
- Kim, Jin Kyoung; Kim, Chung Su; Ahn, Hyun Joo; Bang, Si Ra; Kim, Sung Joon; Yoo, Hae Young; Jeong, Han-Sin
- Issue Date
- Nov-2010
- Publisher
- ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
- Keywords
- Radiation; Epidermal growth factor; Epithelium; Short circuit current; Ion transport
- Citation
- BIOMEDICINE & PHARMACOTHERAPY, v.64, no.9, pp 594 - 599
- Pages
- 6
- Journal Title
- BIOMEDICINE & PHARMACOTHERAPY
- Volume
- 64
- Number
- 9
- Start Page
- 594
- End Page
- 599
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/55306
- DOI
- 10.1016/j.biopha.2010.06.005
- ISSN
- 0753-3322
1950-6007
- Abstract
- Recombinant human epidermal growth factor (rhEGF) has potential benefit for the mucositis induced by radiation therapy as a therapeutic setting. In this study, we aimed to investigate the effects of rhEGF treatment on the radiation-induced changes in epithelial transport function, before the occurrence of the definitive histological mucosal changes. C3H/He mice received 0, 4, or 8 Gy irradiation and/or EGF treatment (rhEGF 0, 1 and 5 mg/kg, i.p., 5 days). At day 7, we recorded short circuit current (I-sc) of the upper tracheal epithelium using the flow-type Ussing chamber method, with histological analysis. As a result, there was no evident pathological change in the epithelium from the irradiated and/or rhEGF treated mice at day 7. The initial level of I-sc and amiloride-sensitive I-sc (Delta I-sc,I-Amil) were decreased after 8 Gy irradiation, reflecting suppression of basal Na+ absorption. The decreased 6,1,Amil was recovered by rhEGF treatment. In conclusion, epithelial Na+ channel-dependent basal Na+ absorption was primarily affected by irradiation, before the pathological changes. The recovery of basal Na+ absorption (Delta I-sc,I-Amil) suggested a potentially beneficial effect of early rhEGF treatment for irradiation-induced suppression of the upper aerodigestive epithelial functions. (C) 2010 Elsevier Masson SAS. All rights reserved.
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Collections - Red Cross College of Nursing > Department of Nursing > 1. Journal Articles
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