Bacillus Calmette-Guérin 무반응성 근육층 비침습성 방광암의 새로운 치료약제들New Drugs for Bacillus Calmette Guérin-Unresponsive Nonmuscle Invasive Bladder Cancer
- Authors
- 정재운; 하재백; 장인호
- Issue Date
- Dec-2021
- Publisher
- 대한비뇨기종양학회
- Keywords
- Antibody-drug conjugate; Bacillus Calmette-Guérin; Immune checkpoint inhibitors; Oncolytic virotherapy; Urinary bladder neoplasms
- Citation
- 대한비뇨기종양학술지, v.20, no.1, pp 12 - 24
- Pages
- 13
- Journal Title
- 대한비뇨기종양학술지
- Volume
- 20
- Number
- 1
- Start Page
- 12
- End Page
- 24
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/55565
- DOI
- 10.22465/kjuo.2022.20.1.12
- ISSN
- 2234-4977
- Abstract
- For intermediate- and high-risk nonmuscle invasive bladder cancer (NMIBC), intravesical Bacillus Calmette-Guérin (BCG) therapy is the standard adjuvant treatment following transurethral resection of bladder tumor. Although intravesical BCG therapy improves disease progression and bladder preservation in most patients, there are still a considerable number of BCG-unresponsive cases, for whom radical cystectomy (RC) is the recommended salvage treatment option. However, RC is associated with high morbidity and mortality rates, and alternative treatment options are needed. New approaches, such as intravesical chemotherapy, device-assisted treatments, immune checkpoint inhibitors, viral gene therapy, antibody-drug conjugates, fibroblast growth factor receptor inhibitors, and other novel agents are being investigated. This review aims to provide an overview of the recent trials for BCG-unresponsive NMIBC.
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