l-카라기난의 유동학적 성질과 어쥬번트효과Rheological Property and Adjuvant Effect of l-Carrageenan
- Authors
- 김범수; 이광재; 이종형; 조두현; 김윤중; 정병욱; 김하형
- Issue Date
- Jan-2002
- Publisher
- 대한약학회
- Keywords
- ethanol; alcohol detoxicant; Puerariae thunbergiana; Alpiniae katsumadai
- Citation
- 약 학 회 지, v.46, no.1, pp 6 - 10
- Pages
- 5
- Journal Title
- 약 학 회 지
- Volume
- 46
- Number
- 1
- Start Page
- 6
- End Page
- 10
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/56367
- ISSN
- 0377-9556
2383-9457
- Abstract
- Alpinia katsumadai is used in traditional oriental medicine as an antiemetic and for treatment of stomach disorders.
This study was to investigate the effect of the 50% methanol extract of Alpinia katsumadai and Puerariae thunbergiana
on ethanol metabolism in rat. The administration of 50% methanol extract of Alpinia katsumadai significantly
decrease the ethanol concentration in rat. The AUC and Cmax of Alpinia katsumadai was 3.1 and 2.4 times less than the
control group, respectively. It was more effective than Pueraria thunbergiana is known to as ethanol detoxicant. Furthermore,
we tested on its ethanol metabolizing effect with the preparation containing this herb (Haeju pill) in beagle. The
AUC of Haeju pill was about 1.9 times less than the control group. It was estimated that the extract of Alpinia katsumadai
had feasibility as a ethanol detoxication agent.
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