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HCL에 의한 식도염에서 식도와 하부괄약근의 점막과 근육세포의 염증변화Inflammatory Changes in Esphagus Sphincter of HCL-elicited Esophagitis in Cats
- Issue Date
- 2002
- Publisher
- 대한약학회
- Keywords
- Esophagitis; phospholipase A2; myeloperoxidase; histamine
- Citation
- 약 학 회 지, v.46, no.1, pp 58 - 62
- Pages
- 5
- Journal Title
- 약 학 회 지
- Volume
- 46
- Number
- 1
- Start Page
- 58
- End Page
- 62
- ISSN
- 0377-9556
2383-9457
- Abstract
- The underlying mechanism by which the reflux of gastric juice elicits oesophagitis remains unclear. To investigate inflammatory response to HC1 in tissue of esophagus and lower esophageal sphincter, experimental esophagitis was elicited by perfusion of 0.1 N HC1 in cats. There was no difference in phospholipase A 2 (PLA2) activity of tissue between control and esophagitis. Myeloperoxidase activity in esophagitis was significantly greater than that of control. However, histamine content in esophageal mucosa of esophagitis was significantly smaller than that of control. These findings suggest that inflammatory response to HC1 in esophagitis is related to changes of myeloperoxidase activity and histamine rather than change of PLA2 activity.
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