COX-2 억제제가 누드마우스에 이식된 위암세포주에서 종양의 성장과 전이에 미치는 영향
DC Field | Value | Language |
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dc.contributor.author | Oh, Joung-Sik | - |
dc.contributor.author | Sim, Woo Jung | - |
dc.contributor.author | Cha, Sung Jae | - |
dc.contributor.author | Chi, Kyong Choun | - |
dc.contributor.author | Park, Sung Jun | - |
dc.contributor.author | Lim, Hyun Muk | - |
dc.contributor.author | Park, Sung Il | - |
dc.contributor.author | Lee, Tae Jin | - |
dc.contributor.author | Park, Eon Sub | - |
dc.date.accessioned | 2022-04-13T06:40:22Z | - |
dc.date.available | 2022-04-13T06:40:22Z | - |
dc.date.issued | 2002-02 | - |
dc.identifier.issn | 2288-6575 | - |
dc.identifier.issn | 2288-6796 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/56396 | - |
dc.description.abstract | Purpose: Tumor invasion and metastasis are known to be extremely important factors in the prognosis of cancer patients. Although recent studies have demonstrated that cyclooxygenase-2 (COX-2) is overexpressed in various cancers including gastric cancer, the mechanisms underlying the contribution of COX-2 to tumorigenesis and tumor promotion remain unclear. Methods: In order to determine the role of COX-2 in tumor growth and metastasis, we investigated COX-2 expression, apoptosis and the expression of E-cadherin, CD44v6, MMP-2 and TIMP-2 in gastric cancer xenografts treated with meloxicam (a selective COX-2 inhibitor). Results: Cells from the MKN45 gastric cancer cell line that overexpress COX-2 were inoculated subcutaneously into athymic mice. Oral administration with meloxicam reduced the tumor volume (P<0.01), induced apoptosis of cancer cells (P<0.01), suppressed the proliferation rates (P<0.01), increased the expression of E-cadhrin (P<0.05) and reduced the expression of MMP-2 and TIMP-2. Conclusion: The above data showed that COX-2 inhibitors can inhibit tumor growth and suppress metastatic potential by expression of adhesion molecules and suppression of metalloproteinases, suggesting that this inhibitor can be used as an additive anti-cancer drug in cases of stomach cancer with radical resection, although further evaluation is required. (J Korean Surg Soc 2002;62:95-102) | - |
dc.format.extent | 8 | - |
dc.language | 한국어 | - |
dc.language.iso | KOR | - |
dc.publisher | 대한외과학회 | - |
dc.title | COX-2 억제제가 누드마우스에 이식된 위암세포주에서 종양의 성장과 전이에 미치는 영향 | - |
dc.title.alternative | The Effect of COX-2 Inhibitor on the Growth and Metastasis of Gastric Cancer Xenograft | - |
dc.type | Article | - |
dc.identifier.bibliographicCitation | 대한외과학회지, v.62, no.2, pp 95 - 102 | - |
dc.identifier.kciid | ART000919709 | - |
dc.description.isOpenAccess | N | - |
dc.citation.endPage | 102 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 95 | - |
dc.citation.title | 대한외과학회지 | - |
dc.citation.volume | 62 | - |
dc.publisher.location | 대한민국 | - |
dc.subject.keywordAuthor | COX-2 | - |
dc.subject.keywordAuthor | Gastric cancer | - |
dc.subject.keywordAuthor | Tumor growth | - |
dc.subject.keywordAuthor | Metastasis | - |
dc.subject.keywordAuthor | COX-2 | - |
dc.subject.keywordAuthor | Gastric cancer | - |
dc.subject.keywordAuthor | Tumor growth | - |
dc.subject.keywordAuthor | Metastasis | - |
dc.subject.keywordAuthor | COX-2 | - |
dc.subject.keywordAuthor | 위암 | - |
dc.subject.keywordAuthor | 종양의 성장 | - |
dc.subject.keywordAuthor | 전이 | - |
dc.description.journalRegisteredClass | kciCandi | - |
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