COX-2 억제제가 누드마우스에 이식된 위암세포주에서 종양의 성장과 전이에 미치는 영향The Effect of COX-2 Inhibitor on the Growth and Metastasis of Gastric Cancer Xenograft
- Authors
- Oh, Joung-Sik; Sim, Woo Jung; Cha, Sung Jae; Chi, Kyong Choun; Park, Sung Jun; Lim, Hyun Muk; Park, Sung Il; Lee, Tae Jin; Park, Eon Sub
- Issue Date
- Feb-2002
- Publisher
- 대한외과학회
- Keywords
- COX-2; Gastric cancer; Tumor growth; Metastasis; COX-2; Gastric cancer; Tumor growth; Metastasis; COX-2; 위암; 종양의 성장; 전이
- Citation
- 대한외과학회지, v.62, no.2, pp 95 - 102
- Pages
- 8
- Journal Title
- 대한외과학회지
- Volume
- 62
- Number
- 2
- Start Page
- 95
- End Page
- 102
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/56396
- ISSN
- 2288-6575
2288-6796
- Abstract
- Purpose: Tumor invasion and metastasis are known to be extremely important factors in the prognosis of cancer patients. Although recent studies have demonstrated that cyclooxygenase-2 (COX-2) is overexpressed in various cancers including gastric cancer, the mechanisms underlying the contribution of COX-2 to tumorigenesis and tumor promotion remain unclear.
Methods: In order to determine the role of COX-2 in tumor growth and metastasis, we investigated COX-2 expression, apoptosis and the expression of E-cadherin, CD44v6, MMP-2 and TIMP-2 in gastric cancer xenografts treated with meloxicam (a selective COX-2 inhibitor).
Results: Cells from the MKN45 gastric cancer cell line that overexpress COX-2 were inoculated subcutaneously into athymic mice. Oral administration with meloxicam reduced the tumor volume (P<0.01), induced apoptosis of cancer cells (P<0.01), suppressed the proliferation rates (P<0.01), increased the expression of E-cadhrin (P<0.05) and reduced the expression of MMP-2 and TIMP-2.
Conclusion: The above data showed that COX-2 inhibitors can inhibit tumor growth and suppress metastatic potential by expression of adhesion molecules and suppression of metalloproteinases, suggesting that this inhibitor can be used as an additive anti-cancer drug in cases of stomach cancer with radical resection, although further evaluation is required. (J Korean Surg Soc 2002;62:95-102)
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