Effects of lifestyle modification on metabolic parameters and carotid intima-media thickness in patients with type 2 diabetes mellitus
DC Field | Value | Language |
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dc.contributor.author | Kim, So Hun | - |
dc.contributor.author | Lee, Suk Jeong | - |
dc.contributor.author | Kang, Eun Seok | - |
dc.contributor.author | Kang, Shinae | - |
dc.contributor.author | Hur, Kyu Yeon | - |
dc.contributor.author | Lee, Hyun Joo | - |
dc.contributor.author | Ahn, Chul Woo | - |
dc.contributor.author | Cha, Bong Soo | - |
dc.contributor.author | Yoo, Ji Soo | - |
dc.contributor.author | Lee, Hyun Chul | - |
dc.date.accessioned | 2022-04-25T08:40:22Z | - |
dc.date.available | 2022-04-25T08:40:22Z | - |
dc.date.issued | 2006-03 | - |
dc.identifier.issn | 0026-0495 | - |
dc.identifier.issn | 1532-8600 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/56758 | - |
dc.description.abstract | The aim of this study was to examine the effects of a 6-month intensive lifestyle modification intervention on metabolic parameters and carotid intima-media thickness (IMT) in patients with type 2 diabetes mellitus. Fifty-eight subjects with type 2 diabetes mellitus were randomly assigned to the intervention group or the control group. The subjects in the intervention group participated in a 16-week intensive lifestyle modification program and subsequent monthly meetings during the 6-month study period. Control subjects received basic dietary education and usual care. Anthropometric data, metabolic parameters, and carotid IMT were examined before the intervention and after 6 months. Lifestyle modification intervention group patients showed a significant reduction in HbA1c (−1.0% ± 1.3% vs +0.1% ± 1.2%, P = .002), fasting blood glucose (−1.6 ± 1.5 vs +0.3 ± 2.5 mmol/L, P = .001), and 2-hour postprandial plasma glucose (−2.1 ± 2.5 vs +0.8 ± 4.4 mmol/L, P = .003) compared with control patients after 6 months. Body weight (−2.0 ± 2.6 vs +0.2 ± 1.7 kg, P = .001), body mass index (−0.8 ± 1.0 vs 0.0 ± 0.8 kg/m2, P = .003), and systolic blood pressure (−8.2 ± 15.9 vs +0.4 ± 14.1 mm Hg, P = .041) were significantly decreased in the intervention group. A significantly reduced carotid mean IMT progression was seen in the intervention group after 6 months (−0.040 ± 0.136 vs +0.083 ± 0.167 mm, P = .007). Changes in HbA1c (r = 0.34, P = .028), fasting plasma glucose (r = 0.31, P = .045), and 2-hour postprandial plasma glucose (r = 0.37, P = .015) correlated with the mean carotid IMT change after adjustment for age and sex. In conclusion, a 6-month intensive lifestyle modification intervention in patients with type 2 diabetes mellitus resulted in improved glycemic control and decreased progression of carotid IMT. | - |
dc.format.extent | 7 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.title | Effects of lifestyle modification on metabolic parameters and carotid intima-media thickness in patients with type 2 diabetes mellitus | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.metabol.2006.03.017 | - |
dc.identifier.bibliographicCitation | Metabolism: Clinical and Experimental, v.55, no.8, pp 1053 - 1059 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-33745917735 | - |
dc.citation.endPage | 1059 | - |
dc.citation.number | 8 | - |
dc.citation.startPage | 1053 | - |
dc.citation.title | Metabolism: Clinical and Experimental | - |
dc.citation.volume | 55 | - |
dc.type.docType | Article | - |
dc.publisher.location | 미국 | - |
dc.description.journalRegisteredClass | scopus | - |
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