Effects of lifestyle modification on metabolic parameters and carotid intima-media thickness in patients with type 2 diabetes mellitus
- Authors
- Kim, So Hun; Lee, Suk Jeong; Kang, Eun Seok; Kang, Shinae; Hur, Kyu Yeon; Lee, Hyun Joo; Ahn, Chul Woo; Cha, Bong Soo; Yoo, Ji Soo; Lee, Hyun Chul
- Issue Date
- Mar-2006
- Citation
- Metabolism: Clinical and Experimental, v.55, no.8, pp 1053 - 1059
- Pages
- 7
- Journal Title
- Metabolism: Clinical and Experimental
- Volume
- 55
- Number
- 8
- Start Page
- 1053
- End Page
- 1059
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/56758
- DOI
- 10.1016/j.metabol.2006.03.017
- ISSN
- 0026-0495
1532-8600
- Abstract
- The aim of this study was to examine the effects of a 6-month intensive lifestyle modification intervention on metabolic parameters and carotid intima-media thickness (IMT) in patients with type 2 diabetes mellitus. Fifty-eight subjects with type 2 diabetes mellitus were randomly assigned to the intervention group or the control group. The subjects in the intervention group participated in a 16-week intensive lifestyle modification program and subsequent monthly meetings during the 6-month study period. Control subjects received basic dietary education and usual care. Anthropometric data, metabolic parameters, and carotid IMT were examined before the intervention and after 6 months. Lifestyle modification intervention group patients showed a significant reduction in HbA1c (−1.0% ± 1.3% vs +0.1% ± 1.2%, P = .002), fasting blood glucose (−1.6 ± 1.5 vs +0.3 ± 2.5 mmol/L, P = .001), and 2-hour postprandial plasma glucose (−2.1 ± 2.5 vs +0.8 ± 4.4 mmol/L, P = .003) compared with control patients after 6 months. Body weight (−2.0 ± 2.6 vs +0.2 ± 1.7 kg, P = .001), body mass index (−0.8 ± 1.0 vs 0.0 ± 0.8 kg/m2, P = .003), and systolic blood pressure (−8.2 ± 15.9 vs +0.4 ± 14.1 mm Hg, P = .041) were significantly decreased in the intervention group. A significantly reduced carotid mean IMT progression was seen in the intervention group after 6 months (−0.040 ± 0.136 vs +0.083 ± 0.167 mm, P = .007). Changes in HbA1c (r = 0.34, P = .028), fasting plasma glucose (r = 0.31, P = .045), and 2-hour postprandial plasma glucose (r = 0.37, P = .015) correlated with the mean carotid IMT change after adjustment for age and sex. In conclusion, a 6-month intensive lifestyle modification intervention in patients with type 2 diabetes mellitus resulted in improved glycemic control and decreased progression of carotid IMT.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - Red Cross College of Nursing > Department of Nursing > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/56758)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.