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Effects of methanol on expression of an anticoagulant hirudin in recombinant Hansenula polymorpha

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dc.contributor.authorKim, M.-D.-
dc.contributor.authorKang, H.-A.-
dc.contributor.authorRhee, S.-K.-
dc.contributor.authorSeo, J.-H.-
dc.date.accessioned2022-04-29T07:40:13Z-
dc.date.available2022-04-29T07:40:13Z-
dc.date.issued2001-07-
dc.identifier.issn1367-5435-
dc.identifier.issn1476-5535-
dc.identifier.urihttps://scholarworks.bwise.kr/cau/handle/2019.sw.cau/56999-
dc.description.abstractA series of batch, fed-batch, and continuous cultures was carried out to analyze the effects of methanol on the fermentation characteristics of recombinant Hansenula polymorpha for the production of hirudin, an anticoagulant. Hirudin expression efficiencies were greatly influenced by the methanol concentrations in continuous and fed-batch culture modes. At a steady state of continuous culture, an optimum methanol concentration of 1.7 g l(-1) was determined ata dilution rate of 0.18 h(-1) with 1.8 mg l(-1) h(-1) hirudin productivity.-
dc.format.extent4-
dc.language영어-
dc.language.isoENG-
dc.publisherNATURE AMERICA INC-
dc.titleEffects of methanol on expression of an anticoagulant hirudin in recombinant Hansenula polymorpha-
dc.typeArticle-
dc.identifier.doi10.1038/sj.jim.7000163-
dc.identifier.bibliographicCitationJOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY, v.27, no.1, pp 58 - 61-
dc.description.isOpenAccessN-
dc.identifier.wosid000171055800010-
dc.identifier.scopusid2-s2.0-0034786086-
dc.citation.endPage61-
dc.citation.number1-
dc.citation.startPage58-
dc.citation.titleJOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY-
dc.citation.volume27-
dc.type.docTypeArticle-
dc.publisher.location미국-
dc.subject.keywordAuthorHansenula polymorpha-
dc.subject.keywordAuthorHirudin-
dc.subject.keywordAuthorMethanol-
dc.subject.keywordAuthorMethanol oxidase promoter-
dc.subject.keywordPlusSACCHAROMYCES-CEREVISIAE-
dc.subject.keywordPlusMETHYLOTROPHIC YEASTS-
dc.subject.keywordPlusGENE-EXPRESSION-
dc.subject.keywordPlusPROTEINS-
dc.subject.keywordPlusOXIDASE-
dc.subject.keywordPlusCULTURES-
dc.relation.journalResearchAreaBiotechnology & Applied Microbiology-
dc.relation.journalWebOfScienceCategoryBiotechnology & Applied Microbiology-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
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자연과학대학 (생명과학과)
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