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Research Progress on Natural Diterpenoids in Reversing Multidrug Resistance
- Authors
- Deng, Zheo-fen; Bakunina, Irina; Yu, Hua; Han, Jaehong; Dömling, Alexander; Ferreira, Maria.-Jose U; Zhang, Jian-ye
- Issue Date
- Mar-2022
- Publisher
- Frontiers Media S.A.
- Keywords
- cancer; chemotherapy; diterpenoids; multidrug resistance; natural products
- Citation
- Frontiers in Pharmacology, v.13
- Journal Title
- Frontiers in Pharmacology
- Volume
- 13
- ISSN
- 1663-9812
1663-9812
- Abstract
- Multidrug resistance (MDR) is one of the main impediments in successful chemotherapy in cancer treatment. Overexpression of ATP-binding cassette (ABC) transporter proteins is one of the most important mechanisms of MDR. Natural products have their unique advantages in reversing MDR, among which diterpenoids have attracted great attention of the researchers around the world. This review article summarizes and discusses the research progress on diterpenoids in reversing MDR. Copyright © 2022 Deng, Bakunina, Yu, Han, Dömling, Ferreira and Zhang.
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