Cloning of mouse sepiapterin reductase gene and characterization of its promoter region
DC Field | Value | Language |
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dc.contributor.author | Lee, Soo Woong | - |
dc.contributor.author | Park, In Young | - |
dc.contributor.author | Hahn, Yoonsoo | - |
dc.contributor.author | Lee, Ji Eun | - |
dc.contributor.author | Seong, Chang Soo | - |
dc.contributor.author | Chung, Jae Hoon | - |
dc.contributor.author | Park, Young Shik | - |
dc.date.accessioned | 2022-05-13T01:40:26Z | - |
dc.date.available | 2022-05-13T01:40:26Z | - |
dc.date.issued | 1999-04 | - |
dc.identifier.issn | 0167-4781 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/57595 | - |
dc.description.abstract | We have isolated and characterized similar to 5 kb mouse sepiapterin reductase gene (Spr) and a highly homologous pseudogene (Sprp). The authentic Spr gene is present as a single copy in the mouse genome and is composed of three exons containing the entire coding region. The primer extension experiment located the transcription initiation site in a putative pyrimidine-rich Inr element. The promoter region of the Spr gene is embedded within a CpG island. It was shown that the promoter region is devoid of distinctive TATA and CAAT boxes. Transient transfection of a series of 5' deletion derivatives of the Spr promoter showed the sequence between -83 and -51 to be essential for promoter activity. The pseudogene Sprp lacks promoter region and exon 3. (C) 1999 Elsevier Science B.V. All rights reserved. | - |
dc.format.extent | 7 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | ELSEVIER SCIENCE BV | - |
dc.title | Cloning of mouse sepiapterin reductase gene and characterization of its promoter region | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/S0167-4781(99)00030-5 | - |
dc.identifier.bibliographicCitation | BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION, v.1445, no.1, pp 165 - 171 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000079892100017 | - |
dc.identifier.scopusid | 2-s2.0-0013687930 | - |
dc.citation.endPage | 171 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 165 | - |
dc.citation.title | BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION | - |
dc.citation.volume | 1445 | - |
dc.type.docType | Article | - |
dc.publisher.location | 네델란드 | - |
dc.subject.keywordAuthor | tetrahydrobiopterin | - |
dc.subject.keywordAuthor | promoter | - |
dc.subject.keywordAuthor | luciferase assay | - |
dc.subject.keywordAuthor | pseudogene | - |
dc.subject.keywordPlus | CYCLOHYDROLASE-I GENE | - |
dc.subject.keywordPlus | TETRAHYDROBIOPTERIN BIOSYNTHESIS | - |
dc.subject.keywordPlus | TRANSCRIPTION FACTOR | - |
dc.subject.keywordPlus | ALDOSE REDUCTASE | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | CDNA | - |
dc.subject.keywordPlus | ORGANIZATION | - |
dc.subject.keywordPlus | INITIATOR | - |
dc.subject.keywordPlus | DATABASE | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Biophysics | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biophysics | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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