LINKAGE OF PHOSPHORIBOSYLPYROPHOSPHATE SYNTHETASE-1 AND SYNTHETASE-2, PRPS1 AND PRPS2, ON THE MOUSE X-CHROMOSOME
- Authors
- LEE, K; KEITZ, B; TAIRA, M; CHAPMAN, VM
- Issue Date
- Jun-1994
- Publisher
- SPRINGER VERLAG
- Citation
- MAMMALIAN GENOME, v.5, no.10, pp 612 - 615
- Pages
- 4
- Journal Title
- MAMMALIAN GENOME
- Volume
- 5
- Number
- 10
- Start Page
- 612
- End Page
- 615
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/57698
- DOI
- 10.1007/BF00411455
- ISSN
- 0938-8990
1432-1777
- Abstract
- The X Chromosome (Chr) genes for phosphoribosylpyrophosphate synthetases 1 and 2, Prps1 and Prps2, were mapped on the mouse X Chr with interspecific backcrosses between C57BL/6 (B6) and M. spretus (S). Southern analysis showed that Prps1 mapped between Plp and DXWas31, a mouse X Chr region that is homologous to Xq21-24 on the human X Chr while Prps2 mapped between DXWas31 and Amg, a region that is homologous to the map position of PRPS2 on Xp22 of the human X Chr. Additionally, other restriction fragments highlighted by PRS II showed autosomal segregation. In situ hybridization and FISH analysis of metaphase chromosome spreads prepared from lymphocytes of B6 or S male mice confirmed that there were in fact two different locations on the X Chr, X F1-2 and X F2-3 for Prps1 and 2 respectively, as well as two autosomal sites for Prps-like genes.
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